Ke Yuan
@keyuan1Senior Lecturer @GlasgowCS @UofGlasgow | Machine Learning & Computational Biology
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Big news: We just released PLM-interact, a tool for predicting protein-protein interactions, showing a 16-28% improvement over previous methods and even predicting mutation effects on interactions. Here’s the story behind this journey. 🧵👇
🚀 Our new preprint is out! We show that protein language models can predict protein-protein interactions by jointly encoding protein pairs, leading to significant improvements in PPI prediction. biorxiv.org/content/10.110…
If anyone is around today @CRUK_SI at noon I’ll be presenting some of recent work on @EvolTherapy focused on prostate cancer, melanoma and basal cell carcinoma @mathonco @MoffittNews
A 4th funded PhD scholarship in my lab, to work on best methods for screening organoids (collab: Crispin Miller and Neil Carragher). USING DATA SCIENCE AND ADVANCED IMAGING ON PATIENT-MATCHED MINI-AVATARS TO IMPROVE PRECISION MEDICINE APPROACHES. gla.ac.uk/postgraduate/d…
Can protein language models be adapted to accurately predict protein-protein interactions across different species and mutation scenarios? @UofGlasgow @biorxivpreprint "PLM-interact: extending protein language models to predict protein-protein interactions" • The prediction…
PLM-interact: extending protein language models to predict protein-protein interactions 1. PLM-interact introduces a novel approach to predict protein-protein interactions (PPIs) by jointly encoding protein pairs, leveraging a method similar to “next sentence prediction” in NLP.…
Great to be involved in this work, applying information retrieval techniques to other types of language models - we show that cross-encoders can be used to predict if proteins will interact. We also apply our PLM-interact model for predicting virus-host interactions
New preprint on @DanLiu_'s @viroinf PhD research in collaboration with @keyuan1, @ir_glasgow, @DiRAC_HPC and others: PLM-interact: extending protein language models to predict protein-protein interactions biorxiv.org/content/10.110…
🚀 Our new preprint is out! We show that protein language models can predict protein-protein interactions by jointly encoding protein pairs, leading to significant improvements in PPI prediction. biorxiv.org/content/10.110…
New preprint on @DanLiu_'s @viroinf PhD research in collaboration with @keyuan1, @ir_glasgow, @DiRAC_HPC and others: PLM-interact: extending protein language models to predict protein-protein interactions biorxiv.org/content/10.110…
PhD position opportunity to work an interdisciplinary team at the @UofGlasgow in AI tools to uncover critical host-virus interactions... Exciting 🙌. If not for you, please share with anyone you think might be interested 👌. Thanks 👍
📣 Interested in AI and biology? PhD position at @robertson_lab on predicting virus-host interactions using protein language models. An exciting collab w/ @david_l_robertson, @ir_glasgow (myself), @keyuan1 and @AlfredoCast Apply 👉 gla.ac.uk/colleges/mvls/…
A second (funded) opportunity to do a super cool and highly collaborative PhD project between my lab @owen_sansom @keyuan1 & @LeQuesneLab, making chimeric tumours in vivo. Check it out! gla.ac.uk/colleges/mvls/… gla.ac.uk/colleges/mvls/…
📣 Interested in AI and biology? PhD position at @robertson_lab on predicting virus-host interactions using protein language models. An exciting collab w/ @david_l_robertson, @ir_glasgow (myself), @keyuan1 and @AlfredoCast Apply 👉 gla.ac.uk/colleges/mvls/…
📢We are delighted to announce that the Beatson International Cancer Conference, "Cancer Models: from Data to Discovery" will take place on Tuesday 27th - Thursday 29th May 2025 in Glasgow, Scotland! Follow us here to get the latest conference updates! #BICC2025
📢Junior Group Leader positions📢 Call for ECRs looking to establish an independent research programme with CRUK, Wellcome, UKRI, ERC or other fellowship funding within our leading cancer research facilities Find out more and register your interest here: crukscotlandinstitute.ac.uk/careers/group-…
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