Kwasi Adu-Berchie
@kaduberchiePhD from @Harvard @wyssinstitute #MooneyLab
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Great to see that our work was selected as @natBME cover image
The November cover illustrates that the viscoelasticity of extracellular matrices can be altered to generate functionally distinct T-cell populations from T cells that received the same stimulation. go.nature.com/47r0Wnq rdcu.be/drbP7 [Paper]
I am excited to be selected as a 2024 #STATWunderkind. You can find my story and other STAT Wunderkinds here: statnews.com/meet-the-2024-…
Excited to share my recent postdoc work on developing surface-functionalized microgels as artificial antigen‐presenting cells for T cell expansion and regulation of their phenotypes and cytotoxic functions. onlinelibrary.wiley.com/doi/abs/10.100…
Genome-wide image-based screening to identify regulators of STING trafficking!🚦🚓 Such a fun journey working on this with "team STING": co-first authors @mgentili_ and @BingxuL!
Happy to share this manuscript as a goodbye to the Broad. This would have not been possible without @beccajcarlson and input from @BingxuL biorxiv.org/content/10.110… We used Optical Pooled CRISPR Screens to classify genes regulating STING trafficking A 🧵
Congratulations @beccajcarlson!
I’m excited to share a new manuscript from my PhD! doi.org/10.1101/2024.0… We performed a genome-wide optical pooled screen (OPS) and identified hundreds of novel Ebola virus regulators.
Congratulations @nikkommunology and team
what happens when a bioengineer, biophysicist, and immunologist smash their brains together? me, @JoshuaBrockman1 @YunhaoZhai @DonIngber report to you a #mooneylab review on the potential of taking advantage of TCR biophysics in immunotherapy 💖✨ doi.org/10.1063/5.0166…
Thanks to @TheScientistLLC for highlighting our work!
May the mechanical force be with you! Chemical stimulation is commonly used to shape T cell function, but @kaduberchie and his colleagues @wyssinstitute explored how mechanical cues also tune these immune cells. @NatBME Read the story here: bit.ly/3LLxBeY
This study from the Mooney lab is just another beautiful example of how biophysics give context to biochemistry and how biophysics can direct T cell maturation nature.com/articles/s4155…
Thanks to @wyssinstitute for highlighting our work!
Biomaterial one-two punch developed at the Wyss and @hseas researchers allows to treat tumors with combination immunotherapy. @kaduberchie @NatureComms #Immunotherapy #CancerResearch wyss.harvard.edu/news/biomateri…
Taking a cue from the emerging data on tissue-specific effects on T cell phenotypes, @kaduberchie @wyssinstitute @hseas found that viscoelasticity (time-dependent response to stress), but not stiffness, impacted T cell RNA signatures [...] bit.ly/44oiQFY
Excited that our work on generating phenotypically and functionally distinct T cell populations by altering matrix viscoelasticity has been published
Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix rdcu.be/dfqEb
Out now in @PNASNews, our first scaling of #opticalpooledscreening (OPS) to genome-wide level. We leveraged our high-res image-based phenotyping approach and enhanced it with machine learning to study how cells regulate response to Sendai virus infection pnas.org/doi/10.1073/pn…
We had a great session on Diagnostics led by David Walt and are finishing one on Therapeutics led by Dave Mooney. We've heard about projects from Light-Seq to DoriVac to Biostasis. #Diagnostics #Therapeutics #CancerVaccine #WyssRetreat22
Congrats again to our outstanding poster awardees - @kaduberchie (@Harvard), @johnhickey22 (@Stanford), @KGriffin_DVMPhD (@ucdavis), Haleigh Eppler (@UofMaryland), Kristen Rodrigues (@MIT) & Elizabeth Curvino (@DukeU). Very well deserved! #IEgrc2022
Congratulations to our poster awardees. Well deserved! #IEgrc2022
The Woappi Laboratory for Synthetic Regeneration and Systems Physiology is hiring at all levels📢! We have multiple fully-funded positions to advance the understanding of wound physiology. Come join us in creating a new era of tissue regeneration! woappilab.com
Thanks for being on my thesis committee @SMitragotri! Your comments, feedback and encouragements were invaluable to my PhD journey.
It was a pleasure to be a thesis committee member of @kaduberchie What a wonderful thesis defense! The story of his personal journey was as inspiring as the narration of his scientific accomplishments! @hseas @wyssinstitute
Excited to share our new paper @JOrthopRes that shows how surgical repair increases Achilles tendon inflammation and reduces tendon markers in early healing @SoslowskyLab @kaduberchie @ORSsociety @ors_tendon onlinelibrary.wiley.com/doi/10.1002/jo… ..If only we had an alternative to suturing..🐌
Super excited to finally share our work! Here we suggest how mechanotherapy helps severely injured skeletal muscle to heal faster. #MooneyLab, #Conor Walsh's Biodesign Lab, @wyssinstitute, @hseas, …science-org.ezp-prod1.hul.harvard.edu/doi/10.1126/sc…
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