Jan Philipp Kreysing
@jpkreysingPhD student - Cellular biophysics (cryo-ET) | @MPIbp @Beck_Laboratory @IMPRS_CBP
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Very happy that our work on HIV nuclear entry is now out as a preprint. Check out the thread for a summary. The most surprising finding was that the capsid appears to crack the NPC scaffold as revealed by cryo-ET and template matching. #teamtomo t1p.de/gdez6
In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).
… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. rdcu.be/d3dmN
Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵
We are excited to announce the publication of high confidence 3D template matching for #cryoET @HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience Paper's link: nature.com/articles/s4146… See it in action in our short video!
Check out now why thinner is not always better 👉science.org/doi/10.1126/sc… Congratulations on this fantastic work to the authors M. W. Tuijtel, @SergioCruzLeon1, @jpkreysing, @sonjawelsch, G. Hummer (@HummerLab), M. Beck (@Beck_Laboratory) and B. Turonova 🥳
Can highly recommend applying to this PhD program. I'm now in my third year here and couldn't be happier. @imprs_cbp @MPIbp
Looking for a #PhDposition in the #LifeSciences? #Apply to our #gradschool on cellular #biophysics! Prepare your documents & contact your referees. We look foward to get to know you👉imprs-cbp.mpg.de/call-for-appli… #imprs #phd @goetheuni @uni_mainz @fias_science @MPIbp @maxplanckpress
In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).
Looking for a #PhDposition in the #LifeSciences? #Apply to our #gradschool on cellular #biophysics! Prepare your documents & contact your referees. We look foward to get to know you👉imprs-cbp.mpg.de/call-for-appli… #imprs #phd @goetheuni @uni_mainz @fias_science @MPIbp @maxplanckpress
How can genetic perturbation of a central scaffolding component of the #nuclearpore result in a tissue specific defect? Work by @Reiya_Tan1guch1 and others in collaboration with @DoyeValerie makes this more conceivable (@MPIbp @IJMonod): biorxiv.org/content/10.110…
Great to see this method out as a preprint now. It has been an invaluable tool for me over the last months.
🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯 doi.org/10.1101/2023.0…
![SergioCruzLeon1's tweet image. 🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯 doi.org/10.1101/2023.0…](https://pbs.twimg.com/media/F5X3f6FW0AASYs3.jpg)
Excited to share our in situ #CryoET story on the effect of a top antimalarial drug candidate on the translational landscape in #CryoFIB-milled malaria parasites! So proud of this massive team effort with @leonie_anton @_wenjing_cheng_ @mehsehret @davwcbb🥰#officially #teamtomo
In situ cryoET reveals inhibitor-induced perturbations in Pf80S GTPase interactions biorxiv.org/cgi/content/sh… #bioRxiv
🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯 doi.org/10.1101/2023.0…
Thinner is not always better: Optimising cryo lamellae for subtomogram averaging biorxiv.org/cgi/content/sh… #bioRxiv
Scientists from our @Beck_Laboratory have visualized the structural dynamics of ribosomes in human cells for the first time. Using #cryoET, they generated 3D images of ribosomes in action & deciphered the target site & mode of action of a leukemia drug 👉biophys.mpg.de/cellular-decod…
Tomographic structures of ribosomes from the inside of human cells at decent resolution reveal translation dynamics. Congrats to @HuaipengXing @Reiya_Tan1guch1 @iskhusainov @jpkreysing @sonjawelsch & B Turonova. #CryoEM #teamtomo @MPIbp @SCALE_Uni_FFM science.org/doi/10.1126/sc…
Have you already submitted your #application? If not, get your documents ready and #apply now! Only 1 week left till the deadline🏁Don't miss this opportunity if you are looking for a #PhDposition in the #lifesciences! 👉imprs-cbp.mpg.de/call-for-appli… @goetheuni @fias_science @uni_mainz
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