Teferi Merid
@janmersiyAssistant professor of medicine, consultant internist, GI and Hepatology fellow
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This Clinical Insights discusses new diagnostic criteria, risk stratification, and emerging treatments of metabolic dysfunction–associated steatotic liver disease. ja.ma/4idg79U
Top-down infliximab plus azathioprine versus azathioprine alone in patients with acute severe ulcerative colitis responsive to intravenous steroids: a parallel, open-label randomised controlled trial, the ACTIVE trial @Gut_BMJ @PeyrinBiroulet gut.bmj.com/content/early/…
1/11 ⏰ for #EBGI Tweetorial🧵w/ @Montalvan214 & @SantaellaMD! “ACG Guideline on Treatment of Helicobacter pylori: New recommendations…Will practice change?” 📜 tinyurl.com/2vmfu7c3 🎧 tinyurl.com/yck5v4z2 📰 tinyurl.com/5ebrnnfx
#CGH4ALL @AGA_CGH📣 🔍New📰 letter on constipation & redundant colon ➡️63% w/ ≥1️⃣dolichocolon criteria 🚫no difference in transit time or colonic volume vs. non-dolichocolon 📰Learn more🔗 doi.org/10.1016/j.cgh.… Reported by @arianapg @jeffreyrfetzer @eamonnquigleymd
Overall HCV seroprevalence in Ethiopia was 0.18% and higher seroprevalences were found in Afar (0.92%).Journal of Viral Hepatitis, 2024; 0:1–11 doi.org/10.1111/jvh.14… Seroprevalence of Hepatitis C in Ethiopia
NORMAL Alanine Aminotransferase (ALT) ▪️34 U/L for male ▪️22 U/L for female 🔗 cghjournal.org/article/S1542-… 🙏 @AGA_CGH
#CGH4ALL We presently define “normal” ALT as 95th percentile of ‘presumed’ healthy 💪🏻 population. Is that enough? 🛑 This new 🔖 in @AGA_CGH defines ALT reference limits using both 🧪 & 🔬 🔗doi.org/10.1016/j.cgh.… Report by @NAggarwalMD
There have been a lot of recent changes in the world of MASLD - how to make sense of it all?! Never fear. Neha Shah and Arun Sanyal provide us with a pragmatic approach in @AmJGastro #RedJournal Link: journals.lww.com/ajg/citation/9…
Several promising blood-based biomarkers/panels are in various phases of validation. GALAD is furthest along. Shows promise for 📈 sensitivity for early stage HCC detection and likely increased adherence to surveillance! Potential to reduce mortality in HCC 🙏 @AmJGastro
💡 In Crohn’s disease (CD) patients with intestinal stenosis, ustekinumab (UST) showed higher steroid-free remission at week 52 vs. infliximab (IFX) (69.8% UST vs. 51.8% IFX). 📊 A multicenter study providing real-world insights: 🔗 journals.sagepub.com/doi/epdf/10.11…
The LIR!C study, published in 2017, helped redefine the role of early surgery for patients with #Crohns disease - bit.ly/3A4D0Ft #IBD #LancetGastroHep5
Excited to share our RWD comparing TOF, FIL, and UPA in UC. ・UPA -> the highest efficacy ・UPA -> low discontinuation rate, but high acne risk ・HZ risk -> comparable ・High platelet counts -> lower FIL efficacy ・Long dis duration -> better TOF efficacy onlinelibrary.wiley.com/doi/10.1111/ap…
@IRACON2024 ! Attending the Oration by the master himself, Dr John stone, who for those unaware has authored the chapter on IgG4 RD in Harrison's ! Key takeaways in slides ! #Rheumtwitter Not all raised IgG4 is IgG4RD Raised IgG4 is the new "ANA" !! "7" key lessons !
Congratulations to @syedahmed92 for presenting his thesis work on carvedilol in CSPH.. based on Non invasive test (LSM >20kpa) used for prevention of decompensation.@AASLDtweets @AnandVKulkarni2 @drsridhars @Yujun__Wong @Sanchit30497977
#Frontiers24 @StMarksHospital Can we stop #IBD therapies @MLongMD ✅Stopping TNFi in pts in remission ->relapse w/in 1yr even if pt on AZA ✅Assess risk of dis progression off therapy ✅Counsel pts on risk of de-escalation, need for close monitoring, plan B for relapse
Early surgery 🤜🤛 Endoscopy first in Chronic Pancreatitis: long term outcomes (100 months FU) 😓 Pain score / complete relief 😅 and patient satisfaction all favor surgery 🪡 Is early surgery the best approach?! Comments? 🧐 jamanetwork.com/journals/jamas…
🌟 Our first-ever living guideline for managing moderate-to-severe #UlcerativeColitis led by @berkeleydoc, @manasiagrawalmd, @Jhaydek, @ashwinmdibd, @FrankIScottMD, @EdwardLoftus2 prioritizes early use of advanced therapies over a step-up approach. ow.ly/t2Ru50UahEi
📢 Live from #TLM2024 HCC debrief by Neehar Parikh ➡️ Liver stiffness may help refine HCC screening in MASLD pts ➡️ Are lower AFP levels better than the usual cutoffs for screening cured HCV, ALD, and MASLD patients? @AASLDtweets
#TLM2024 ALD & MetALD debrief by @juanpabloarab ➡️ Steroid tapering trial in alcohol-hepatitis ⬇️ infections vs standard approach ➡️ Many ALD pts are MetALD ➡️ In ALD, men and private insurance favors LT ➡️ Larsucosterol trial for alcohol-hepatitis @AASLDtweets @alehlatam
Ivabradine in combination with Carvedilol in Cirrhotic Cardiomyopathy @docMPK with another fabulous work Upping the cardiac-liver interface @INASL_Liver @HepatologyPGI @AnandVKulkarni2 @ajay_duseja @dean_karvellas @kumarrahul0204
🔸Practice changing Late Breaking Oral @AASLDtweets TLM#2024 by ✨ @AnandVKulkarni2 🔸Challenging established nuances in Alc Hep steroid usage 🔸Tapering dose 🆚 standard dose in steroid responder 🏅🏅 Tapering Strategy 📉 Infection @docMPK @ebtapper @JasmohanBajaj @INASL_Liver
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