Jonathan KM Lim 林家铭
@j0nlimCancer biologist; raised in Malaysia, trained in Canada. Currently @HHU_de Interested in oncogenic RAS biology, cancer metabolism, noncoding RNA
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🔬 Illustrating the timeliness of our work, a Japanese research team has recently published related findings in @NatureSMB nature.com/articles/s4159….
We are beyond excited to share our latest work on the role of PRDX6 in #ferroptosis out today in @MolecularCell and spearheaded by two exceptional postdocs in our lab, Junya and @eikan_em ! cell.com/molecular-cell…
Excited to share our new paper led by @mattabolite in collaboration with Saharon Rosset showing that the Warburg Effect is the result of faster ATP production by glycolysis than respiration. A 🧵... 1/n pnas.org/doi/10.1073/pn…
Online Now: Tumor-suppressive activities for pogo transposable element derived with KRAB domain via ribosome biogenesis restriction dlvr.it/TFtZhq
💥Cheeky 'little' update from @GencodeGenes v47, almost doubling the number of #lncRNA genes & ~4x more lncRNA transcripts. This was highlighted by @1QINGWANG when observing the greater quality of our reference-guided de novo TxOme assemblies from deep direct RNA sequencing data
Oncometabolites at the crossroads of genetic, epigenetic and ecological alterations in cancer nature.com/articles/s4141…
Amazing Crete Conference 2024 with so many friends and awesome discussions @ToiberDebbie @OdedRechavi @BarakRotblat @GrunewaldLab @AGLeprivier
Excited to share the first research publication from our lab! Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking sciencedirect.com/science/articl…
Reprogramming tumor cells to fight cancer | Science science.org/doi/10.1126/sc…
"The generation of lactate is a well-established feature of cells w/mito dysfunction. This...has led to the conclusion that in the absence of functional ETC, pyruvate is entirely redirected toward lactate production. Our findings...challenge this belief." nature.com/articles/s4146…
😊 Here is @AncelyF 🎉 #NewsViews on two recent studies by the groups of #saveriotardito and @andMORand published in @EmboMolMed Troubling bonds: lipid unsaturation promotes selenium dependency and sensitivity to ferroptosis | EMBO Molecular Medicine embopress.org/doi/full/10.10…
In this issue focusing on #CellDeath: ☕️Toshitaka Nakamura & Marcus Conrad discuss in a Review #ferroptosis vulnerabilities in #cancer. 👉🏿rdcu.be/dVZTn nature.com/articles/s4155…
Epigenetic dysregulation is widespread in cancer. Using a new in vivo method, we generated a phenotypic roadmap of 250 epigenetic regulators in lung tumorigenesis in vivo. Most critical epigenetic tumor suppressors including one I hadn’t heard of before. biorxiv.org/content/10.110…
🥳🎉🎉!!!New paper out! We developed antibody-peptide inhibitor conjugates to block cathepsins in specific cells nature.com/articles/s4158… It is a new drug design spearheaded by @aa_petruzzella and a beautiful and fun collaboration with @befcorreia @EPFL_en @epflSV
🫧 Special Issue! #LipidDroplets in Health and Disease 👩🔬 Guest editors: @MariaBohnert & @BiancaSchrul ➡️ bit.ly/44SET8Z 16 reviews highlight new discoveries in the lipid droplet lifecycle and insights into diseases related to lipid storage. @wwu_muenster @Saar_Uni
Good morning all. An incredibly packed curated issue of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/20… "There's no exploration anymore, except in a very few places." -Sydney Brenner
Thank you Thomas!!! So happy for the long run collaboration!
Awesome work from @AGLeprivier and @BarakRotblat !
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism | Nature Communications nature.com/articles/s4146…
Glucose is essential for life. How do cells survive when glucose is low? How is that relevant for cancer? See our latest study together with @BarakRotblat rdcu.be/dHVvd 👇👇👇👇👇
Excited to announce that Hannes Beyer (@HHU_de) and I are hiring a postdoc to join us on our @VolkswagenSt Pioneering Research project to develop a novel therapeutic strategy against cancer. Please forward to your colleagues that might be interested! linkedin.com/jobs/view/3926…
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