Henri Niskanen
@henri_niskanenPostdoctoral researcher @MPI_MolGen, PhD (Molecular Medicine) @UniEastFinland, MSc (biochemistry) @UniTurku, occasional musician
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Happy to share our work published today in @Nature, where we show that a subset of disease-associated variants in intrinsically disordered regions (IDRs) result in aberrant phase separation and nucleolar dysfunction. nature.com/articles/s4158…
Genetic evidence for functional specificity in biomolecular condensates: nature.com/articles/s4157… Free read only copy: rdcu.be/dXDvY @bsabari @idpsig @HymanLab @PappulabWashU @Pha_Tran_Papers @NatureRevGenet @MPI_MolGen #Condensates #IDR
It was a pleasure working with @dhnisz and @HymanLab on this article for @NatureRevGenet where we review results from experimental and disease genetics that together provide insights into cellular functions and molecular specificity of condensates: nature.com/articles/s4157…
Can transcription factors be optimized? Exciting work from @Naderij_ and @alexpmagalhaes revealed a trade-off between specificity and activity. Great to see this study finally out! Congrats to all authors!
Human TFs face a molecular trade-off between activity and specificity encoded as submaximal dispersion of aromatic residues in their disordered regions. A collaborative effort of @dhnisz, @VingronLab and Graf Lab published today in @NatureCellBio nature.com/articles/s4155…
Birte from #germanscholars paid me a visit at #MPI_MolGen couple of weeks ago. We had a nice chat and it was great to learn how GSO supports us Boost Fellows! To current and soon-to-be postdocs: I highly recommend to apply for KT Boost Fund in the next rounds!
Our Journey Continues with our KT Boost Fellow @henri_niskanen, who explores a "killswitch" peptide @MPI_MolGen that could manipulate cellular condensates, leading to new treatments.
A fascinating work is published today @Nature by Zhang & Zhang et al. on a serendipitous discovery of haemoglobin expression outside the RBC cells--in chondrocytes--and their critical role in keeping our cartilage alive under an oxygen-deprived environment.…
I'm proud to announce I was selected to receive funding from Klaus Tschira Boost Fund @germanscholars @ktstiftung and I'm excited to proceed with our work on modulating the properties of #biomolecular_condensates Thanks Hnisz-lab, @dhnisz and @MPI_MolGen for their support!
𝗠𝗲𝗲𝘁 𝘁𝗵𝗲 𝗻𝗲𝘄 𝗞𝗹𝗮𝘂𝘀 𝗧𝘀𝗰𝗵𝗶𝗿𝗮 𝗕𝗼𝗼𝘀𝘁 𝗙𝘂𝗻𝗱 𝗙𝗲𝗹𝗹𝗼𝘄𝘀 Here they are: Our 𝟭𝟲 𝗻𝗲𝘄 𝗙𝗲𝗹𝗹𝗼𝘄𝘀 with backgrounds in #ComputerScience, #Physics, #Biology, #Neurosciences & #EarthSciences. ➡️ Learn more about them:lnkd.in/e-xZrt64
Me trying to explain to a foreigner what's going on in Finland right now:
Our lab is seeking talented candidates for the #MSCAPostdoctoral Fellowship call 2023 in Functional Genomics Guided Risk Prediction of #Atherosclerotic #CardiovascularDisease. Please spread the word and DM us for more info #PostdocJobs #AcademicTwitter euraxess.ec.europa.eu/jobs/100023
Brilliant and concise article on disordered proteins and why they matter, by @alisonmsnyder: Dogma-defying biology axios.com/2023/02/11/bio… Shoutout: @PappulabWashU @alexholehouse @LaskerKeren, Peter Wright & John Jumper @DeepMind @MPI_MolGen
Nature research paper: Aberrant phase separation and nucleolar dysfunction in rare genetic diseases go.nature.com/3YjZVsP
Malfunction of cellular condensates: new research uncovers molecular mechanism that could explain how numerous unexplained diseases develop mpg.de/19845284/0206-… @matertius @henri_niskanen @malte_spielmann et al. at @dhnisz @ChariteBerlin @berlinnovation @MPI_MolGen @UKSH_KI_HL
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