ASHansen Lab
@hansen_labWe seek to understand the molecular mechanisms that regulate genome organization and gene expression in time and space. Based in @MITdeptofBE
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@TjianDarzacq
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Congrats to @ViraatGoel James Jusuf et al. on new preprint in collab with @Irate_Physicist @blobelgroup @leonidmirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes: biorxiv.org/content/10.110…
(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup @leonidmirny biorxiv.org/content/10.110… RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator
Come and see James' BATS talk today
First BATS of the academic year 2024/25 🥳! James Jusuf (@hansen_lab): “Genome-Wide Absolute Quantification of Chromatin Looping” ow.ly/Coyb50ThrOE
Congrats to @GavinSchlissel @Pulin_Li with single-molecule imaging contribution from @DomenicNarducci @hansen_lab Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: pnas.org/doi/10.1073/pn…
Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab . Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.110… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.110…
Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin! biorxiv.org/content/10.110…
Bittersweet to say goodbye to Christos last week - Thanks for 2 fantastic years and all the best for grad school at Columbia!
Congrats to Ava @AvaConyer on a fantastic MSRP poster presentation on the polycomb work she did together with Sumin @suminkim28 !
Check out Sarah's new review on bidirectional promoters: sciencedirect.com/science/articl…
Excited to share Sarah's new review on BiDirectional Promoters (BDPs). Sarah discusses 6 molecular mechanisms that may account for unique transcriptional properties of BDP with a focus on noise regulation and co-expression: authors.elsevier.com/a/1jI5c,LqArU0…
We are thrilled to welcome Coco Wu to the lab as a new graduate student from the @MITBiology graduate program co-advised with @fjsanchezrivera - Coco is interested in exploring the relationship between DNA sequence, DNA looping, gene expression, and disease!
Congrats to @proteinnns, Hui Si, @clee_bio, @liaulab on this new paper on LSD1 with imaging contributions from @DomenicNarducci sciencedirect.com/science/articl…
Lastly, our work highlights how resistance mutations can be invaluable discovery tools (see our review for more examples). Huge thanks to the team that made this work possible! Esp @proteinnns, Hui Si, @clee_bio, @Malvina_Pap, @hansen_lab & @liaulab (7/7) nature.com/articles/s4158…
Excited to welcome Jack Toppen to the lab as a new graduate student who joins us from the @MITCSBPhD graduate program - Jack is interested in developing computational tools for understanding and modeling transcriptional bursting.
Thrilled to welcome Masahiro Nagano to the lab as a new post-doc with fellowships from JSPS and HFSP - Masahiro is interested in understanding 3D genome structure and function relationships during germ cell differentiation.
Congratulations to incoming post-doc Masahiro Nagano on winning an HFSP post-doc fellowship: we look forward to working with you!
And here it is, the CLASS OF 2024!🤩💪Congratulations to the 59 top emerging postdoctoral scientists awarded 2024 #HFSPFellowships!🥳🎉Are you one of them?🫵Discover the #frontierprojects that will foster next generation of #lifesciences👏bit.ly/3VKe7wM #2024HFSPAwardees
Check out @DomenicNarducci 's new preprint biorxiv.org/content/10.110… and the companion preprint from @deWitLab biorxiv.org/content/10.110…
(1/14) Excited to share our new work on ZNF143/ZFP143 by @DomenicNarducci ZNF143 has been widely reported to be a general loop factor Instead we and @deWitLab in a companion preprint show that ZNF143 is a TF with no loop function: biorxiv.org/content/10.110… biorxiv.org/content/10.110…
Check out @JinHarveyYang 's review on Enhancer Selectivity, Spatiotemporal Enhancer-Promoter mechanisms, caveats of 3C and Imaging based methods, the Facilitator role of CTCF, and much more: nature.com/articles/s4158…
(1/n) Excited to share our new review by @JinHarveyYang @NatRevMCB We discuss: 1) spatiotemporal mechanisms of E-P interactions 2) mechanisms of enhancer selectivity 3) pros and cons of 3C and imaging based methods Brief summary thread below: nature.com/articles/s4158…
Thrilled to change title to Associate Professor and see this recognition of the lab's work:
Congratulations to Paul C. Blainey @BlaineyLab on his promotion to Full Professor and to Anders Sejr Hansen @Anders_S_Hansen @hansen_lab for his promotion to Associate Professor without Tenure. Please join us in congratulating Paul and Anders. @broadinstitute @kochinstitute
Also slightly delayed, but we are also excited to welcome to the lab: Allison Vieira Michael Quezada Varshini Ramanathan ashansenlab.com/news/welcome-a…
Slightly delayed, but we are are excited to welcome two new undergraduate students to the Lab: Dominique Dang and Sophie Wang ashansenlab.com/news/welcome-d…
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Who to follow
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Tjian + Darzacq Group
@TjianDarzacq -
CTCF Papers 📚
@CTCF_Papers -
Anders Sejr Hansen
@Anders_S_Hansen -
Luca Giorgetti
@LucaGiorgetti -
Wendy Bickmore
@wendy_bickmore -
Elphege Nora Lab at UCSF
@ElphegeNoraLab -
Geoff Fudenberg
@gfudenberg -
Nick Gilbert's Lab
@chromatinlab -
Teif Lab
@TeifLab -
Kazuhiro Maeshima
@kazu_maeshima -
Furlan-Magaril_lab
@FurlanLab -
deWitLab
@deWitLab -
Bintu Lab
@BintuLab -
Takashi Fukaya
@FukayaLab -
International Nucleome Consortium
@INC_COST
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