Gianni Castiglione
@giannicastVanderbilt Asst. Prof, Biological Sciences, Ophthalmology & Visual Sciences
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Had a fantastic visit as the seminar speaker @yale_eeb ! Really stimulating conversations with such down to earth and creative people @Jenn_Coughlan @big_data_kane @TJNear thanks for the invite!
Excited to have our new paper highlighted AND on the cover in MBE!
Excited to share MBE's first Highlight! Learn how Antarctic icefishes have adapted to see under the ice -- Looking through the Ice: Cold-Adapted Vision in Antarctic Icefish buff.ly/3KCxWPo @giannicast @EvolutionVU @opsinlab @franceshauser @alexvn @UofTCellSysBiol
Our paper is out! w @HopkinsMedicine We explore how certain ACE2 mutations granting natural resistance to #SARSCoV2 infection will likely never evolve in humans (but maybe in dogs!) journals.plos.org/plosbiology/ar….
Doomed by our physiology? @giannicast &co argue that, because of epistasis acting on #ACE2, ancient events in mammalian #cardiovascular evolution determined the host range of #SARSCoV2 millions of years before the current pandemic #PLOSBiology plos.io/3pgprAk
Birding in Baltimore: Avian Antioxidant Innovations Predate Modern Medicine by 65 Million Years natureecoevocommunity.nature.com/users/385090-g… #behindthepaper
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds: nature.com/articles/s4146… @giannicast
We found that #Birds have supercharged antioxidants! They lost the master off-switch controlling antioxidant gene expression. This is a major clinical target, which could explain why birds have such long lifespans. Thanks to @LightsOutBalt @NatureComms nature.com/articles/s4146…
Heavy emphasis on story telling in science coms these days is limitting. Narrative arcs with strong characters that experience dramatic tension/ personal change just doesn't fit so much of what is wonderful. Need other models, like arranging a beautiful bouquet, as well.
Our team at @HopkinsMedicine found that human eyes are susceptible to SARS-Cov-2
ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection biorxiv.org/cgi/content/sh… #bioRxiv
Rhodopsins provide a new example showing how evolution's path can be constrained elifesciences.org/digests/35957/…
New eLife paper with @opsinlab "Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision" doi.org/10.7554/eLife.…
We're delighted to announce that SynBio Canada is live! Read the latest #synbio news from Canada and abroad, and join the community at synbiocanada.org
Check out our new paper with @opsinlab demonstrating molecular convergence in the visual system at high altitudes! onlinelibrary.wiley.com/doi/10.1111/ev…
Beyond thermodynamic constraints: Evolutionary history shapes protein sequence variation biorxiv.org/content/early/…
🔬 The visionary research being done by @opsinlab provides an interesting glimpse at evolution in action. ow.ly/IPeC30dt3Y4 #UofT
Read about this neat study in our fresh-off-the-press PNAS paper: pnas.org/content/early/… pic.twitter.com/zXGl8fbbo1 #evol2017
Fish living in extreme environments adapt ability to see ow.ly/Q9l330cVGnS @UofT @opsinlab @giannicast @franceshauser
Gianni Castiglione @giannicast on convergent cold adaptation in high altitude catfish vision #evol2017
@giannicast experimental evidence of nonsynonmous changes do not affect spectral tuning but vision kinetic in high-alt fish opsin #evol2017
First paper published from PhD with @franceshauser @opsinlab @PNASNews - nonspectral adaptation in rhodopsin pnas.org/content/early/…
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