KaiGallant
@gallant_kaiPhD student at the MPI of Molecular Physiology - fascinated by the complexity of the ubiquitin system, PTM erasers, a sustainable future and (gender) equality
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@mpimoph
@IMPRS_LM
@hemmo_lab
@CermakLab
@Zhexin_Wang
@NikolasKlink
@neF1995
@RaRodea16
@DuccioConti
@GolgiLabEssen
@LabWestermann
@ValentinaPian0
@MinghaoChen10
@crc1430
@DvdGently
My PhD work, funded by @wellcometrust, is out now! We showed that the #trafficking and rapid turnover of CTLA4 is #ubiquitin dependent and is linked to a complex architecture of ub chain linkages. Big thanks to @jnpruneda, Almut and Klaus-Peter for this great collab @LivUniISMIB
.@imPeiYee, Urbé et al. @LivUni characterize the role of #ubiquitin in the rapid turnover kinetics of the immune checkpoint protein CTLA4. hubs.la/Q02TqZYr0 #Cancer #Trafficking #Biochemistry #ProteinHomeostasis
Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response - published by the Imig group in @FrontiersIn Molecular Biosciences frontiersin.org/journals/molec…
Excited to share this work from former @PrunedaLab superstar @camgroberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence! biorxiv.org/content/10.110…
Wow – potential breakthrough in developing degraders against neurodegenerative diseases! the RING-bait hijacks protein aggregation to become activated itself and induce breakdown of aggregates like tau in Alzheimer’s. huge congrats to everyone involved cell.com/cell/fulltext/…
📢Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #cellbiology, #chemicalbiology and #syntheticbiology? Applications for the @IMPRS_LM #PhDprogram are now OPEN!!!
We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…
Ubiquitin gets sweet: Sugar-mediated ubiquitination regulates Nrf1 function dlvr.it/TCHHY3
Our latest preprint is now online! We demonstrate that mRNA degradation via deadenylation can be inhibited by targeting the CCR4-NOT complex. Amazing work by @SunitPal_HBS who had to dive deep into a completely new area for us! chemrxiv.org/engage/chemrxi…
Was a lot of fun contributing to this project with my fantastic colleague Kim and everyone involved (in @GerschLab and beyond). I would be very grateful to receive feedback from anyone interested in DUBs, ubiquitin, ubiquitinomics and tricellular junctions! Hope you'll enjoy it😊
For all ubiquitin, deubiquitinase and chemical biology aficionados: Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains. t.ly/GnRVv Thread👇(1/10)
For all ubiquitin, deubiquitinase and chemical biology aficionados: Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains. t.ly/GnRVv Thread👇(1/10)
Attention PTM aficionados ‼️ Why have one PTM on a single amino acid when you can have two! We show that PARP10 mono-ADP-ribosylation is further ubiquitylated in cells! An exciting collaboration between the labs of @MichaelNADbio and @jnpruneda! Short thread below 🧵
Discovery of ester-linked ubiquitylation of PARP10 mono-ADP-ribosylation in cells: a dual post-translational modification on Glu/Asp side chains biorxiv.org/cgi/content/sh… #bioRxiv
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Who to follow
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MPI Dortmund
@mpimoph -
IMPRS for Living Matter
@IMPRS_LM -
HemmoMeyerLab
@hemmo_lab -
Lukas Cermak Lab
@CermakLab -
Zhexin (Eric) Wang
@Zhexin_Wang -
Niko Klink
@NikolasKlink -
Stefan Schmeing
@neF1995 -
Rachel O Dea
@RaRodea16 -
Duccio Conti
@DuccioConti -
HellerschmiedLab
@GolgiLabEssen -
WestermannLab
@LabWestermann -
Valentina Piano
@ValentinaPian0 -
Minghao Chen
@MinghaoChen10 -
CRC 1430
@crc1430 -
Davide Tamborrini
@DvdGently
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