Souradip Mukherjee
@dip_cryoStructural biology enthusiast. #cryoEM #cryoET #cryoFIB #teamtomo @CentrioleLab
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Here is our latest mini-review on the molecular architecture of ciliary transition zones. @CentrioleLab @MerceyOlivier
Our new mini review about the molecular architecture of the ciliary transition zones is out. @MerceyOlivier & @dip_cryo discuss recent cryo-ET and super-resolution work in this field, as well as the structural and molecular variability of TZ. sciencedirect.com/science/articl…
To all the cilia people (all the non-cilia ones as well), check out this cool worl from @MerceyOlivier
New insights into the molecular defects in photoreceptor cilia that drive retinitis pigmentosa, uncovered with ultrastructural expansion microscopy! Check out @MerceyOlivier's paper: embopress.org/doi/full/10.10… #UExM
New ultrastructure expansion microscopy approach reveals details of cilia at nanoscopy resolution Image made with @LeicaMicro 📷: @louvel_vincent et al @CentrioleLab @Biologie_UNIGE in @NatureComms ➡️: bpod.org.uk/archive/2024/1…
Check this out to know our story
Check this one if you want to know better the @CentrioleLab ☺️☺️journals.biologists.com/jcs/article/13…
Expansion microscopy on over 200 species! Check out our collaborative work with the @dudin_o and @Dey_Gautam groups: Charting the landscape of cytoskeletal diversity in microbial eukaryotes. Congrats @F_Mikus @Armanduuum and @HiralABShah !!!
1/9 Insanely PROUD to share our new collaborative project with @Dey_Gautam & @CentrioleLab #PlanExM We think (almost certain) #Expansion #Microscopy (#UExM) is a turning point for #Protistology and #Cell Biology. 🔗 [tinyurl.com/PlanExM1]
Nobel prize for left handed alpha helix
The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have…
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
The Team!!!
New lab picture :) ! ! A wonderful gift from the amazing Elisa Paulin, who has been with us for the last 3 months for her Master's internship.
Santa came by this morning with a LEICA Thunder cryo-CLEM and a new EM GP2 for our @DCI_EM facility at @UNIGEnews :) Merry Christmas to all!
Expansion pushing the resolution barrier
Its out !!! 🥳 Very proud to announce that my PhD work is now published in Nature communication: nature.com/articles/s4146… We developed #iUExM, an optimized iterative expansion protocol allowing 16 to 26 fold homogeneous expansion together with specific bright labelling !
Today is the second anniversary of DCI-Lausanne, and we're thrilled to share the incredible news: Our amazing team (especially Sergey and Inay), has just gifted us with the extraordinary achievement of a 1.12A ApoF structure from the Titan without an energy filter! 🚀 @DCI_EM
Have you ever wanted to see the organelle architecture in cells using a simple fluorescence microscope? If so, this workshop is for you! We are organizing an EMBO workshop on Ultrastructure Expansion Microscopy (U-ExM). Registration is now open: embl.org/about/info/cou…
ChatGPT writing sonnets on cryo-EM. The world is truly changing.
Now that we have a king, these sorts of events will all take much longer, since he can only move along the floor one square at a time. #queensfuneral
Enough twitter for today
- "AlphaFold DB will boldly go where no scientist has gone before!" - PhD student in the lab: 🙂"Hold my beer - let my experimental data fix it"
AlphaFold DB will boldly go where no scientist has gone before. With over 200 million protein structure predictions added to the database, AlphaFold DB now gives users open access to a 3D protein universe. #AlphaFold @DeepMind ebi.ac.uk/about/news/tec…
Really amazing work!
We report a colossal membrane association that contains all four respiratory complexes! 150 proteins + 311 lipids = 5.8 MDa megacomplex that curves the membrane. Tour-de-force by Alex Muhleip @KockFlygaard @OutiHaapanen @vivekvivsharma Amandine and co. 1/7 biorxiv.org/content/10.110…
Honoured to have Bharat Ratna Prof CNR Rao at the inauguration of the MS Lab for Frontier Biology at @jncasr - it was a philanthropic privilege to further science in the Science City of our country 🙏
#cryoET making its mark in #autophagy
How do #membranes transform during #autophagy? Check out our new preprint on BioRxiv! Spearheaded by @anna_bieber_ab and @CristinaCpt Amazing collaboration with Brenda Schulman, Wolfgang Baumeister, Gerhard Hummer @HummerLab, and Philipp Erdmann @3P1L biorxiv.org/content/10.110…
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