Diego Prost
@diegomprostMedical oncologist | Neuro-oncology fellow at @HopPitieSalpe
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From the October issue: Perivascular NOTCH3+ Stem Cells Drive #Meningioma Tumorigenesis and Resistance to Radiotherapy - by @abrarc, Martha Cady, @LabRaleigh, and colleagues @UCSF @NeurosurgUCSF @UCSFCancer bit.ly/3YHwvrz
Systemic treatments in recurrent or metastatic salivary gland cancer: a systematic review - @ESMO_Open esmoopen.com/article/S2059-… ✅ Better outcomes are associated with histology, treatment response, and targeted therapy. Proud to collaborate with: @HParisStJoseph @IstTumori
Online Now: Spark in the darkness: Discovering action potentials in brain tumors dlvr.it/TF0c2r
📢 Just published in JCO! What is the optimal chemotherapy for oligodendroglioma patients? Our study using data from the national prospective cohort POLA found better PFS and OS outcomes with first-line RT/PCV compared to RT/TMZ ascopubs.org/doi/10.1200/JC…
Online Now: GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant dlvr.it/TCmn8Q
Online Now: Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors dlvr.it/TCb3kZ
New Policy Review: Translating the #theranostic concept to #neurooncology: disrupting barriers thelancet.com/journals/lanon…
#Multiomics and drug screening analyses of 50 patient-derived #glioma cell lines reveal molecular subtypes with potential clinical relevance and MYC/MYCN-amplifications #CancerResearch @NatResCancer nature.com/articles/s4146…
Functional CRISPR screens in GBM patient identifies the PTP4A-ROBO1 axis as a driver of tumorigenicity and enriched ROBO1 expression in recurrent GBM that can be targeted via ROBO1-directed CAR T cell therapy @sheilasinghlab @CDCR_Mac @chokshi_c nature.com/articles/s4159…
Excited to share our new review in @NatRevDrugDisc covering ongoing efforts to therapeutically target chromatin remodelers focusing on SWI/SNF complexes. Congratulations to authors @HaydenMalone3 and Charlie! @stjudegraduate @stjuderesearch #swisnf (1/9) nature.com/articles/s4157…
Out in ESMO Open - First-in-human phase 1 trial of a novel MDM2/p53 inhibitor (alrizomadlin) in patients with advanced solid tumors. Evidence of strong MDM2 engagement, restoration of p53 function and early clinical activity. esmoopen.com/article/S2059-…
In today's Cell, we propose a “developmental constraint” model whereby cancer cell state plasticity is restricted by the organism’s developmental map to access progenitor-like states and differentiated-like states of adjacent lineages.🧵⬇️ sciencedirect.com/science/articl… @AyushiPatel3994
Online Now: Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators dlvr.it/T7M3Pt
Single Cell Atlas: a single-cell multi-omics human cell encyclopedia genomebiology.biomedcentral.com/articles/10.11…
Last @charlesrudin lab #plasticity abstract in poster session today at #AACR24. CDC7 inhibition prevents neuroendocrine transformation on targeted therapy in both #LungCancer and #ProstateCancer @MSKCancerCenter @MSK_DeptOfMed
Online Now: Shifting the landscape: The role of IDH inhibitors in glioma cell fate dlvr.it/T54Vc2
➡️Molecular and clinical diversity in primary central nervous system lymphoma 🧠 annalsofoncology.org/article/S0923-… ➡️ctDNA tracking 🩸🧬of minimal residual disease in early-stage TNBC in the c-TRAK TN trial annalsofoncology.org/article/S0923-… 2/2
Great work!!! Congratulations @IsaienceHdz! Molecular and clinical diversity in primary central nervous system lymphoma annalsofoncology.org/article/S0923-…
It was an honor to welcome Mariano Socolovsky, MD from University Buenos Aires to give the 6th Annual UCSF Dr. David G. Kline Peripheral Nerve Lectureship this morning. He kicked off our annual peripheral nerve teaching day by discussing brain plasticity and nerve transfers.
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