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Bogdan

@bohdyone

Software engineer. Sceptical but open-minded. Not satisfied until I know how it works!

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Bogdan Reposted

I come back to you now, at the turn of the tide.

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I do enjoy Malcolm's writing

The legal case – naming a few names | Dr. Malcolm Kendrick. Excellent! #Statins drmalcolmkendrick.org/2024/10/30/the…



How much does he pay you to post this fluff piece? 😏

I bet my mortgage Bryan Johnson will live to at least 200. Not because he spends $2,000,000/year biohacking his body. But because he developed the most evidence-based longevity blueprint anyone can follow for free:🧵

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Bogdan Reposted

🧵The unravelling of AstraZeneca's covid-19 vaccine. It went from being hailed as a lifesaver to getting pulled from the market. I take a look back at what happened. blog.maryannedemasi.com/p/the-unravell… @jikkyleaks @BrianneDressen @P_McCulloughMD @drmelissamccann @ianmcdermottLSO

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Is my thinking anti scientific? Can science refute a causal claim? @ZahcM @DanClintonRN @realDaveFeldman

I'm sorry, but your "how science works" hand waving doesn't make logical sense. If you say X is causal, and I can't find any consistent associations for X and the effect, I'm gonna think you're wrong. "Science" cannot be in opposition to basic logic.



If this is true, it's monumentally dumb. I wouldn't believe it, except stuff like this has happened many times before...

I'm sorry, but your "how science works" hand waving doesn't make logical sense. If you say X is causal, and I can't find any consistent associations for X and the effect, I'm gonna think you're wrong. "Science" cannot be in opposition to basic logic.



What makes "fast food" unhealthy?


In 3 minutes @DanClintonRN makes the case that Donanemab, a new Alzheimer's drug, is unsafe, ineffective, and effectively disproves the dominant disease hypothesis. The @US_FDA panel still voted in favour 11:0, ignoring his testimony. Pls share. youtube.com/live/LPdOPydM1…


Chalk this one up to "inappropriate use of causal language with regard to an observed association" Sam. You'd think someone with so many letters after their name would know better, but they never do.

Low carb diets increased ApoB and LDL-C and indecent cardiovascular events.



One minor point, I think waste is an underrated confounder -- peeing sugar is one example you've noted, but also a common one is when people eat more fat than they can digest and it comes out in the stool. Calories in, but never metabolised. Great thread though.

Any time you have a caloric deficit you must have less material than what you started with, so you would weigh less. Likewise, any time you have less material than you started with, as long as you didn't remove it in some other way—amputation and urinating sugar don't count! /3



This is no less true or applicable now than it was 20 years ago. A sad state of affairs, endemic of a broken system. I'm sure @DanClintonRN would agree.

This is one of the most remarkable statements ever given in front of a Senate Committee. Please take 12 minutes and listen closely to what to what is said and then realize that things are much worse now, 20 years later, if you can believe it. Dr. David Graham is an American…



In that case, I think you should clarify that increasing the proportion of PROTEIN DENSE FOODS correlates with satiety. It's not just the raw macronutrient per se, as you mention.

Some people like to boost their protein with powders, but because they're processed (effectivey pre-digested) they don't provide as much satiety or nutrient density. This data is from how 1M+ people live in the real world, not just with protein powders.…



You realise that the CI estimate means that the actual effect in the population being sampled could be anywhere in that range. In the ACM graph for example, the 95% CI crosses 1, meaning no or inverse effect is possible. In fact such a wide CI range implies insufficient data.

3/ MEGA trial (primary prevention with Pravastatin in Japanese): "Coronary heart disease was significantly lower in the diet plus pravastatin group than in the diet alone group (66 events vs 101 events; HR 0.67, 95% СІ 0.49-0.91; р=0.01)." pubmed.ncbi.nlm.nih.gov/17011942/

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Bogdan Reposted

My husband @DavidBaszucki and I were in the audience together watching our son @BaszuckiMatt give this talk about his recovery from #bipolar disorder at the #CoSci conference in Las Vegas--hosted by the most awesome @realDaveFeldman It was the first time Dave and I were…

Our first #CitizenScience Speaker drop of #CoSci is the powerful and very personal story of @BaszuckiMatt connecting the root cause of his #bipolar w/ #metabolism. This is easily one of the most requested talks of #CoSci, and you'll see why. youtube.com/watch?v=01oOw_…



I call it, "the Robocop way"

You know the story of El Salvador, but watch what's happening in Ecuador. After violence erupted in January, President Daniel Noboa has declared a state of internal armed conflict and sent in the troops. The new way of doing things has been called "the Noboa way." Murder in…

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Important article, going into some of the questionable practices in the JUPITER statin trial. Stopping a primary prevention trial after < 2yrs was a genius move by AZ to prevent the possibility of showing increased ACM or other harm over time. @DanClintonRN One for you!

🧵PART 2 - Should rosuvastatin (Crestor®) be withdrawn from the market? Drug safety expert Sidney Wolfe said @US_FDA's approval of the #cholesterol-busting drug was largely based on a flawed trial, hence the drug's licence should be withdrawn. blog.maryannedemasi.com/p/part-2-shoul…



You didn't answer my question. What would you suggest instead for this person who has suffered chronic fatigue for years? Or would you prefer to just make a cheap point instead while ignoring the actual context.

You try reading, it's a post about how the carnivore diet cures all ills but isn't working. Nothing to do with her prior diet. Her ailments may have nothing to do with diet but wait for the advice. " Ignore your doctors" "Drop your meds" "Eat more fat" " Only eat beef"



So even though it reduced the likelihood of the primary composite endpoint, there was not more survival in the "invasive" group. And in fact the invasive intervention was trending towards more deaths as time went on, and likely would have diverged further if the trial went on.

The most important datum from ISCHEMIA is the increased all-cause mortality in the intensive strategy group. Intensively treating patients left more dead. But they spin that as “neutral plus less events” instead of “what I did generated more death indicating futility and/or harm”

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