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Xanthe van Dierendonck, PhD

@XanthevD

🧫🧪🧬 Medical Affairs | SciComm | cardiometabolic health | background in (immuno)metabolism, inflammation, innate immunity, obesity & diabetes mellitus science

Joined November 2013
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Xanthe van Dierendonck, PhD Reposted

Welcome to read the article by Rinke Stienstra and @XanthevD et al.

Interesting research showing glycolytic variability and specificity depend on the type of stimulus. Great insights into the relationship between metabolism of innate immune cells and diabetes. @Immunometaboli2 #diabetes #immunometabolism bit.ly/3hfnzWX

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Happy to see the data from my postdoc at @immunometlab now published! Great effort from everyone involved! 👏

❗️New kind in town of immunomodulatory signaling metabolites in macrophages❗️ We describe D-2HG among the top-induced immunometabolites in inflammatory macrophages that serves as a negative feedback loop to resolve inflammation ➡️sciencedirect.com/science/articl…



Xanthe van Dierendonck, PhD Reposted

It’s out! Our guide for everyone new to studying macrophage metabolism 🧫 @immunometlab @XanthevD @RafaJArguello & our two first authors 👏🏻 An integrated toolbox to profile macrophage immunometabolism cell.com/cell-reports-m…


Xanthe van Dierendonck, PhD Reposted

How lipid droplet flux within macrophages controls inflammation-roles for hypoxia-inducible lipid droplet–associated protein and intracellular adipose triglyceride lipase @PNASNews pnas.org/doi/10.1073/pn…


The last chapter of my Ph.D. thesis was just published in #PNAS! Interested in how the breakdown of triglycerides from lipid droplets can regulate the inflammatory response in macrophages? Read this👉doi.org/10.1073/pnas.2…


It's official! Last week I defended my PhD thesis on #immunometabolism in #obesity and #diabetes, now I'm a doctor and #PhDone. What a great day to finish this PhD journey, thanks to all involved! @WUR @WhatscookingHN @AcademicChatter

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Xanthe van Dierendonck, PhD Reposted

Happy to share publication of our protocols for studying immune cell metabolism in vivo: coupling stable isotope metabolite infusion with bead-based sorting of immune cells. nature.com/articles/s4159… @VAInstitute @VAIMetabolism


So happy to announce that our short spotlight article for @trendscancer on recent work by the @Platten_lab just got published! 😀 Read our thoughts on macrophages and glioma-derived R-2HG here: sciencedirect.com/science/articl…

@XanthevD, Kyra and I just wrote a spotlight article for @trendscancer on the recent @NatureCancer paper from @Platten_lab on the effect of IDH-mutant-derived R-2HG on macrophages in gliomas: sciencedirect.com/science/articl… Coolest cover ever!

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Xanthe van Dierendonck, PhD Reposted

Not sure which technique(s) to select to profile your favorite cell’s immunometabolism? We set up an immunometabolic profiling toolbox and applied it to human and mouse LPS vs IL-4-stimulated “M1/M2” macrophages. We = @RafaJArguello, @XanthevD, @GorkiRike & others not on Twitter

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Xanthe van Dierendonck, PhD Reposted

Proud to share our work extending the concept of #mitohormesis, an evolutionarily conserved stress adaptation promoting #longevity and #metabolic health, to the restraint of #inflammation in the mammalian innate immune system! @NatMetabolism full-text > rdcu.be/ckZId

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Xanthe van Dierendonck, PhD Reposted

Obesity is linked to a risk of certain types of cancer, such as liver cancer and uterine cancer. A recent study provides some clues as to why.


Xanthe van Dierendonck, PhD Reposted

Another great example of immunometabolism research in the single-cell era in @ImmunityCP! We also highlighted the @biorxivpreprint version of this paper in our @Cell_Metabolism perspective (cell.com/cell-metabolis…) @maxim_artyomov

Metabolic states of early-activated CD8+ T cells during the primary immune response | #CyTOF #CD8Tcells #immunometabolism #CAR_Tcells | Lauren Levine, Kamir Hiam-Galvez & Matthew Spitzer @SpitzerLab @InflammatoryDC @JeffRathmell | Immunity @ImmunityCP bit.ly/38vl23M

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Xanthe van Dierendonck, PhD Reposted

Congratulations to Kasparas Petkevicius on publishing his PhD work from the @TVPLab showing that that #norepinepherine makes #macrophages accumulate #fat in @FASEBJournal @TheBHF @MRL_Cam @The_MRC @wellcometrust #lipids #lipotoxicity #immunometabolism dx.doi.org/10.1096/fj.202…

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