@TheWeissLab Profile picture

Norbert Weiss

@TheWeissLab

Neuroscientist @UniKarlova @CharlesUniPRG @3LFUK studying #calcium #ionchannels & #channelopathies | Associate Editor @tandfchannels | Free time @NWeissphotos

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Very interesting chemistry leading to the design of a dual ligand of the α2δ-1 subunit of voltage-gated calcium #ionchannels and the μ-opioid receptor for #pain therapy ➡️ rb.gy/82y57e

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Thanks to Philippe Lory @IGF_Montpellier for this nice Commentary on our recent Review "The T-type #calcium channelosome" #ionchannels ➡️ rb.gy/z1pmve

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New Review: Pathophysiology of ion channels in amyotrophic lateral sclerosis molecularbrain.biomedcentral.com/articles/10.11…



Norbert Weiss Reposted

Our paper on the mechanism of sensitisation of primary sensory neurons by DRG macrophages after nerve injury is out in @GLIA_Journal @WileyNeuro ! onlinelibrary.wiley.com/doi/10.1002/gl…

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REVIEW - Pathophysiology of Ion Channels in Amyotrophic Lateral Sclerosis - Here we discuss the role of #ionchannels in #ALS #MND, their implications on neuronal excitability, and potential as therapeutic target. Credit and congrats go to @RobinStringer ➡️ rb.gy/c24uj9

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Norbert Weiss Reposted

The final version of our @physiolrev editorial is published! Ion channel dysfunction is a hallmark for many diseases. Since ion channels are key therapeutic targets, we anticipate that unraveling new aspects of their dysfunction holds a huge potential towards novel treatments.

Insightful Editorial on "Recent insights into channelopathies" by Dr. Osama F. Harraz @UVMLarnerMed and Dr. Eric Delpire @vumchealth reflect on disruptions in ion channels, known as #channelopathies. ow.ly/M9Gp50Qi650 #CalciumChannels #IonChannels #PotassiumChannels

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Fantastic lecture @IOCBPrague this morning by Gerald Zamponi @zymedyne on targeting T-type #calcium #ionchannels in chronic #pain. Personally very happy to have you in Prague! 🙏

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Norbert Weiss Reposted

A little rant about American universities, in the light on the recent Congressional testimony debacle: Today I learned that Harvard President Claudine Gay seems to have published only 11 peer-reviewed journal papers in her entire academic career. 'So what?', you might ask.…


Norbert Weiss Reposted

Fun opportunity to write a Perspective for @jacionline on the role of peripheral sensory neurons in immunomodulation. #Neuroimmunology Peripheral somatosensory neurons listen and orchestrate the immune response 👇 sciencedirect.com/science/articl…

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Norbert Weiss Reposted

Check out our new review: Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors. @MariaKarela3 frontiersin.org/articles/10.33…

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Can you spot the mistake? 🤣

The model Lagrangian is one of the longest equations in physics because it contains many terms and factors that account for all the possible interactions and symmetries of the Standard Model. It was transcribed by Thomas Gutierrez who derived it from Martinus Veltman's…

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A structural atlas of druggable sites on Nav #ionchannels @tandfchannels ➡️ rb.gy/9jmbq3

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POSTDOC POSITION - Pathophysiology of T-type #calcium #ionchannels in Slobo Todorovic' lab, Denver, Colorado 🇺🇸

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Norbert Weiss Reposted

Just out our new research paper! We identify PIEZO2-dependent rapid pain system in humans and mice. The work led jointly by @OtmaneBouchatta and @M_Brodzki in a close-knit joint effort of @saadsnagi and @SzczotLab groups. 🧵 1/10 👇doi.org/10.1101/2023.1…


REVIEW - The T-type calcium channelosome - Here we compiled the current knowledge surrounding T-type #calcium #ionchannels interactors, their physiological roles, and potential for drug-based therapeutic intervention ➡️ rb.gy/2z7vdt

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Predatory but generous at least 🤨

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Norbert Weiss Reposted

Happy to share a new article from my postdoc in @NCMlab out in @JPhysiol !! In this work, we describe a role for the M-type potassium currents, conducted by KCNQ channels in the differential control of motoneuron subtype recruitment. physoc.onlinelibrary.wiley.com/doi/10.1113/JP…


Norbert Weiss Reposted

New preprint out from the Weir lab, check it out here biorxiv.org/content/10.110…


Norbert Weiss Reposted

Research from Dr. Raj Khanna & team at the NYU Pain Research Center finds that a new compound reversed four types of chronic pain -- outperforming gabapentin without troublesome side effects -- by indirectly targeting calcium channels. nyu.edu/about/news-pub…

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Norbert Weiss Reposted

NEW paper alert from @KhannaLabNYU @nyuniversity @NYUPainResCtr A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain | PNAS pnas.org/doi/10.1073/pn… Especially proud of this one as it represents a 10+ year journey to get here.


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