Sondos Zayed
@SondosZayedMDMD | Radiation Oncologist | The Ottawa Hospital | #WomenWhoCurie | Public Health & Gender Equity advocate | Tweets = Own views | 2023 #WXNTop100
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December 1 2024 podcast on a hot topic Irradiating Polymetastatic Disease -- with Mai Anh Huynh @BrighamRadOnc @drdavidpalma @ebludmir Direct link (right click to download for no cache/skips): redjournal.org/pb-assets/Heal…
Hey Rad Onc residents, check this out ⬇️⬇️⬇️ @ARRO_org @caroresidents @ESTRO_RT
Calling all radiation oncology residents – we’re looking for volunteers to test out new neuroanatomy modules for the ARC Bootcamp! Please email us at neuroarcstudy@gmail.com if interested!
Sharing our NRG pancreas contouring atlas - now in press! Target volume delineation for dose-escalated RT in pancreas cancer has been highly variable, making it difficult to rigorously assess the efficacy and toxicity of RT. redjournal.org/article/S0360-… 1/13
Great piece on history of medical journals & absurdity of publishing industry complex. “a unique & bizarre ecosystem; the ppl who provide both content & external peer review receive no payment from the publisher, who generates revenue from the content.” link.springer.com/article/10.100…
#SBRT for liver metastases: Systematic review and meta-analysis with International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines #radonc practicalradonc.org/article/S1879-…
This intrahepatic cholangiocarcinoma review focuses on future and current strategies, including an algorithm that can be used to drive a personalized and multidisciplinary approach for patients w/ this malignancy. @michael_lidsky @DimitriosMoris Read at: acsjournals.onlinelibrary.wiley.com/doi/full/10.33…
Excited to share about NRG GI-011 (aka LAP100) – anticipated opening in mid/early 2025. In this Phase III RCT, we are assessing the benefit of dose-escalated radiotherapy in patients with locally advanced unresectable pancreas cancer. 🧵1/11
This new #RedJournal article from Tan et al was presented recently at #ASTRO24 during the Scientific Session 32. Read their article on measuring the integration of stereotactic ablative radiotherapy plus surgery for early-stage NSCLC here: tinyurl.com/tanam24
We ❤️ @ASTRO_org! Thanks to everyone for yet another annual conference in the books! We had so much fun at #ASTRO24 and at the debut of our #minimicinterviews! Here is @drviviantan discussing the outcomes of the MISSILE early-stage lung trial!
Presented 🚀 MISSILE 🚀 at #ASTRO2024 Combined ☢️ #SABR and 🔪 #surgery in early 🫁 #NSCLC was safe with reasonable clinical outcomes, but similar to surgery alone 🚨 Publication in RED journal here authors.elsevier.com/sd/article/S03… @drdavidpalma @DrAlexLouie @DrCorreaRO @TimkWin
Here are the long-term outcomes from MISSILE, presented by @drviviantan with concurrent publication in @IJROBP When we started, we were hopeful for an additive or immunologic effect. We didn't find that, but the approach is safe & can be useful in some contexts, like SABR-BRIDGE
Presented 🚀 MISSILE 🚀 at #ASTRO2024 Combined ☢️ #SABR and 🔪 #surgery in early 🫁 #NSCLC was safe with reasonable clinical outcomes, but similar to surgery alone 🚨 Publication in RED journal here authors.elsevier.com/sd/article/S03… @drdavidpalma @DrAlexLouie @DrCorreaRO @TimkWin
Which guidelines have radiation for HCC? @ldawsonmd explains at the first joint JASTRO @ASTRO_org joint education session! #SBRT
👤 NRG-HN005 presented during plenary at #ASTRO2024 #radonc @sueyom 1️⃣ Arm 1: 70 Gy + cisplatin - PFS 98.1% 2️⃣ Arm 2: 60 Gy + cisplatin - PFS 88.6% 3️⃣ Arm 3: 60 Gy + nivolamab - PFS 90.3% ➡️ SOC remains 70 Gy + cisplatin
Finally headed to DC for #ASTRO24. If you're staying til Weds, I will be presenting our NRG consensus contouring atlas for pancreas SBRT. Please join! Room 144, 11:10 AM
Here are the daily pain scores from OPTIMAL - higher scores are worse, light blue is the opioid arm. Superior pain control over the full follow-up period with MMA. We think the scores diverge when the pregabalin gets titrated up.
@SondosZayedMD presenting OPTIMAL at #ASTRO2024 Opioid vs MMA in H&N #cancer 👤 💡 mean pain score during last 7 days RT Opioid 5.10 vs MMA 4.85 (non-inferiority p=0.039, superiority p=0.724) @drdavidpalma @pencilla @DrCorreaRO @goodmanC_MD
Grateful for the opportunity to present OPTIMAL #ASTRO2024 - our pragmatic RCT: #MMA vs opioids for mucositis pain in #HNC 👉#MMA non inf to opioid analgesia last wk of ☢️ and superior for pain relief up to 6 weeks post ☢️ A huge merci to my mentor @drdavidpalma & our team!
This is a bit different #radonc; Lu-177 Dotatate for refractory, high risk treated méningiome WHO 2-3. N=20, demonstrating efficacy. G3 lymphopenia in 50%, anaemia in 5% #ASTR024
☢️Neoadjuvant CRT vs. ChT for initially unresectable locally advanced "Colon" cancer @eClinicalMed ➡️45 patients ✅R0 resection: 80% vs. 20%, P < 0.001 ✅3-year PFS: 76% vs. 45% , P = 0.049 ✅3-year OS: 87.6% vs. 75% , P = 0.037 ✅No differences in severe AEs ❗️Study was…
Some trial caveats (small N, no MMR status, chemo could be longer than XELOX x 4)… But this RCT is a good reminder that for rare case of unresectable colon cancer, chemoRT should be considered for downstaging to facilitate R0 resection. It is even in 2024 NCCN guidelines 🙏!
☢️Neoadjuvant CRT vs. ChT for initially unresectable locally advanced "Colon" cancer @eClinicalMed ➡️45 patients ✅R0 resection: 80% vs. 20%, P < 0.001 ✅3-year PFS: 76% vs. 45% , P = 0.049 ✅3-year OS: 87.6% vs. 75% , P = 0.037 ✅No differences in severe AEs ❗️Study was…
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