Ravi Tharakan
@RaviTharakantweeting vaguely about science
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New preprint from the lab just dropped! Led by former PhD student @palikyras, our work explains how cells exploit the changed biochemistry of their nuclei to cluster CTCF on nuclear speckles and commit to the fate of senescence. A long(ish) thread... biorxiv.org/content/10.110…
This sort of propaganda is infinitely closer to 1930s Europe than any anti-genocide protest on a college campus is.
Today: Destruction, violence and hate overtake college campuses across the country with Jewish students feeling unsafe at their own schools. It is unacceptable, and harkening back to the 1930s in Europe. Our @InsidePolitics show open, here.
Our next installment of epigenetic rejuvenation via age reversal is out: 2 months of OSK gene therapy in mice with glaucoma fully restores their vision, with no evidence of side-effects, even after prolonged use. Congrats to Bruce Ksander, @YuanchengLu, and the entire team 👏🏻🙏…
Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). The paper that defined a field. A single mutation, in a single gene, doubles worm lifespan. There are genes that affect ageing rates and they can be altered.…
RIBOmap for spatially resolved single-cell translatomics is published today! Congrats to the whole team and thanks so much for the constructive feedback and great suggestion from the editor, reviewers, colleagues, and friends! science.org/doi/10.1126/sc…
Finally out! We performed whole-genome bisulfite sequencing on human tissues over the course of aging, to study how the DNA methylation state of the human genome changes with age onlinelibrary.wiley.com/share/ZQYYFFEV…
"Good people, very talented people, almost always turn out good work. We’re talking about the outstanding work, the type of work that gets the Nobel Prize and gets recognition." gwern.net/doc/science/19…
/2 Here's the link, wh/I should have included initially. science.org/content/articl… HT/@pknoepfler
As a casual reminder to reviewers and authors: if you are working on a biology task and you use random cross-validation, you are making a mistake. It's truly disheartening to review a paper and see this because you have no idea just how distorted the results are.
Our new tool for correcting sequence bias in ribosome profiling data, choros, is now live on biorxiv and GitHub! Fantastic work by Amanda Mok who recently finished her PhD in my group. biorxiv.org/content/10.110…
Skeletal muscle is a major regulator of whole-body metabolism and is composed of a diverse mixture of cells and fiber types. TL;DR: New preprint! We measure single muscle fiber proteomes in 15 min/each w/ timsTOF SCP Started 2 yrs ago in Milwaukee w/@CWSundberg Tweetorial👇
Dear right wing billionaires, my research has also been cancelled by the woke left, please send your money trucks to my office.
A rare side-effect of SARS-CoV-2 mRNA vaccines is myocarditis. The prognosis of this side-effect is not well established. Using information from 23+ mil. residents in four countries (🇩🇰,🇫🇮,🇳🇴,🇸🇪), we compared this kind of myocarditis to other types: bmjmedicine.bmj.com/content/2/1/e0… 1/14
Excited to share our nature paper on mitochondrial complexome nature.com/articles/s4158…
If T cells can not undergo "cellular aging", do we conclude that the decline of immunity in the elderly is mainly a result of the environment in which immune cells reside? Brilliant and inspiring paper from Sorens and colleagues!! nature.com/articles/s4158…
Our comprehensive review of #LongCovid has just been published nature.com/articles/s4157… Phenomenal work by @ahandvanish @LisaAMcCorkell @juliamv @NatureRevMicro
I'm delighted to present this story from the Taunton lab @UCSF in its final form! authors.elsevier.com/a/1gPf4L7PXiq%…
NEW: In @ScienceMagazine today, our latest peer-reviewed research shows Exxon scientists predicted global warming with shocking skill & accuracy between 1977 & 2003, contradicting the company's decades of climate denial. THREAD. 📰No pay wall for 2 weeks: bit.ly/ExxonKnew2poin…
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