ರಾಘವೇಂದ್ರ ಬಸವರಾಜ| Raghavendra Basavaraja
@Raghu_Ippadiಕರುನಾಡ ಹಳ್ಳಿ ಹೈದ; Postdoc @penn; Type1 interferon; Tumour immunology; Tregs , CTLs and CAR T; Inflammation for future.
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Each month an #egg is ovulated from the #ovary, starting the journey of reproduction. But how does ovulation occur?🥚 Our latest work in @NatureCellBio led by @LastChrisThomas and @Tabea_Marx, describes the control of #ovulation using live imaging. bit.ly/3Ya8dEL (1/7)
Our new #paper is out in @NatImmunol Applying #spatial transcriptomics at subcellular resolution to 130 ovarian #cancer tumors, followed by data-driven experimental design and high content #CRISPR screens to map immune evasion in ovarian cancer nature.com/articles/s4159… (1/15)
Online now: BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses dlvr.it/TC6gCK
PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies @CellRepMed doi.org/10.1016/j.xcrm…
Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen 1/ nature.com/articles/s4158…
"Embracing #cancer complexity: Hallmarks of systemic disease" It was a privilege to contribute to this #Cell review, with an incredible group of scientists! Our forward-looking perspective ⬇️ - incl. the #tumor #microenvironment as a critical target 🎯 cell.com/cell/fulltext/…
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel nature.com/articles/s4156…
Stimulating study nature.com/articles/s4158…
We are very excited to present the development of Zman-seq (“Zman”, Hebrew for “time”), the 1st technology that measures single-cell transcriptomes and physical time in vivo, led by @D_Birschenkaum, @CuriousKX, @FlorianIngelfi1, @AssafWeiner sciencedirect.com/science/articl…. (1/19)
Chandrayaan-3 Mission: 'India🇮🇳, I reached my destination and you too!' : Chandrayaan-3 Chandrayaan-3 has successfully soft-landed on the moon 🌖!. Congratulations, India🇮🇳! #Chandrayaan_3 #Ch3
Hi everyone~ I am super excited to pre-print my PhD work 🍾 biorxiv.org/content/10.110… See these fireworks (calcium signals)? These are your immune cells, and this is what happens when they talk to one another to try and organize the very earliest stage of your immune response!
The Chapter I of my postdoc journey at @kuchroolab is now online! Beyond our findings, it's been an incredible human experience. We describe a B-cell state expressing checkpoint molecules uncovering Tim-1, as a potent regulator of anti-tumor immunity: nature.com/articles/s4158…. 1/5
1. Excited to share our new paper in @Nature! With over 1000 tumors analyzed by scRNA-seq, we provide a systematic pan-cancer characterization of transcriptional intra-tumor heterogeneity (ITH) nature.com/articles/s4158…
1/15 🧵 I'm thrilled to share the fantastic news that our Pan-Cancer T cell Atlas is now live @NatureMedicine nature.com/articles/s4159… @MDAndersonNews #SingleCell #SpatialOmics #TumorMicroenvironment #CancerImmunotherapy
Elsevier is losing editors
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells ahajournals.org/doi/abs/10.116…
Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancer dlvr.it/SnqT4g
Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment dlvr.it/Sl03LZ
ChemoNETosis: A road to tumor therapeutic resistance dlvr.it/Smgt2g
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy dlvr.it/Skx12X
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