Pradhab Kirupaharan DO
@PKirupaharan🫁 PH / Pulmonary Vascular Disease specialist and enthusiast🫀
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One of my favourite and most provocative studies yet. The result of an amazing collaboration with @CaravitaSergio @cla_baratto @vkittipibul Discrepancy in the Diagnosis of HFpEF: Supine vs Upright Testing 🚨The SUPRIGHT (SUPine/upRIGHT) test ahajournals.org/doi/10.1161/CI… A 🧵...
We wrote a manuscript! Preload insufficiency patients have lower cardiac output, cardiac filling pressures and VO2peak at submaximal effort-a physiologic explanation as to why this population feels lousy with minimal activity. #MECFS #iCPET @PACCSM onlinelibrary.wiley.com/doi/10.1111/ec…
Looking forward to Cleveland Clinic’s PH Summit in just a few months featuring renowned leaders and pioneers in the field of PH. @heresi_gustavo @SamarFarha @CCF_PCCM @RaedDweikMD Register here to join us in person or virtually on Jan 16-17 👇🏾
Join us in Hollywood Beach, Florida for the 2025 Cleveland Clinic Pulmonary Hypertension Summit on January 16-17, 2025! World class speakers discussing the 7th World Symposium on PH. Register by December 13th to save: ccfcme.org/PH2025.
Join us in Hollywood Beach, Florida for the 2025 Cleveland Clinic Pulmonary Hypertension Summit on January 16-17, 2025! World class speakers discussing the 7th World Symposium on PH. Register by December 13th to save: ccfcme.org/PH2025.
New 📝 on non-invasive surrogates of RV-PA coupling as compared to the gold standard invasive PV loop measurement lead by ⭐️ @CCF_IMCHIEFS residents @jemgolbinMD and @neehal_shukla Open access!
Higher HFpEF prob in patients with Grp 1 PH was associated with ⬇️ cardiometabolic stress ⬇️ exercise performance, ⬇️QoL and ⬇️ survival in PVDomics cohort. Important and growing cohort in real world. Will be eager to see how SGLT2i/GLP and sotatercept benefit these pts…
Ever run into a patient in practice where you are scratching your head to sort out if they have group 1 PH or HFpEF ? Turns out they might actually have both diseases. @JACCJournals, we show how to identify these overlap pts with clinical implications authors.elsevier.com/a/1j%7E8h_GjkR…
Improved survival with pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA) in the European chronic thromboembolic pulmonary hypertension (CTEPH) registry @IreneMLang @elie ahajournals.org/doi/full/10.11…
TAPSE/PASP works in #CTEPH too! 🔔 RV-PA coupling improvement after #BPA can be monitored and trended via TAPSE/PASP @ucsdpccm @UCSDCardiology onlinelibrary.wiley.com/doi/full/10.10…
Important mechanistic study showing increased PEEP enhances LV unloading in an experimental model of AMI-CS! Need to leverage this type of study to inform process trials in our CS patients! @SocietyOfCCC @ElliottMillerMD @carlosalviar @jameshorowitzmd @KadoshBernard
Now published before print in @_Anesthesiology 📄 Elevated PEEP unloads the LV in experimental AMI-CS🫀 Preclinical studies enable measurements often not feasible in clinical settings All results here ⬇️⬇️ doi.org/10.1097/ALN.00… #cardiogenicshock #hemodynamics
How do you identify normotensive shock in PE? We show that IVC contrast reflux is a very specific way. sciencedirect.com/science/articl… @PERTConsortium @ThrombosisRese1
A RCT for HIGH risk PE? - no way , cant do it , shouldn’t do it , yup we are doing it @roblookstein @jameshorowitzmd @FMaeWestMD
Congrats to @AthenaisBoucly @OSitbon and @pulmotension network for this important article "Risk stratification refinements with inclusion of haemodynamic variables at follow-up in patients with #PAH" @InsermU999 @SPLF_SocPneumo erj.ersjournals.com/content/64/3/2…
More evidence that SGLT2i are not just diuretics part 3. We show that dapagliflozin improved arterial and venous compliance during exercise. These vascular load related benefits were associated with pcwp reduction. @MayoClinicCV @CircAHA ahajournals.org/doi/10.1161/CI…
Expert Delphi process trying to decipher the definition of identifying and quantifying RV injury and management strategies in respiratory failure receiving VV ECMO. @vaszochios @Drnasap @AbhiDuggalMD @kshekar01 @FOAMecmo @RaedDweikMD @emireles_c @msiuba @CCF_PCCM
RV injury in adults in respiratory #ECMO, rationale & expert position statements on @yourICM 🖇️ bit.ly/ECMORVDelphi ⚖️ consensus definition 🔍 diagnosis 🖥️ echocardiographic indices #POCUS #echofirst 💦 systemic venous congestion indices 🫁 invasive pulmonary hemodynamic…
Phenotypic Shift, Varied Vasculopathy in IPAH - heterogeneity w/in the vascular phenotype & clinical makeup of pts even w/ the same PAH type Nice @accpchest paper by Nossent, Vonk Noordegraaf My commentary @Medscape: medscape.com/viewarticle/va…
ERJ: Early diagnosis of pulmonary hypertension (PH) is critical for effective treatment and management. The PH-EDA is a noninvasive, ECG-based algorithm that has the potential to accelerate the diagnosis and management of patients with PH. bit.ly/3KdYF55
Is this the best review ever written about temp RV MCS? My bias is yes! Congrats to @Carnicelli_Ant & @manreetkanwar for leading this effort w/ outstanding multidisciplinary collaborators. Indications, weaning strategies, anticoag recs, & more. @TheJHLT jhltonline.org/article/S1053-…
I have been spending this AM test driving @EvidenceOpen the worlds leading MEDICAL AI search platform though the crazy world of complex immunologic diseases/pathogenic/epi & clinical conundrums-I am BLOWN away-check this out now @HealioRheum @RheumNow @Lupusreference @EBRheum
📍Current HFpEF algorithms are not sensitive 📍HFpEF pts must have exercise pulmonary hypertension 📍exPHT can be identified non-invasively
Check out👀our latest analysis in @JAHA_AHA Clinical Significance of Exercise Pulmonary Hypertension With a Negative Diastolic Stress Test for Suspected Heart Failure With Preserved Ejection Fraction | Journal of the American Heart Association (ahajournals.org) 1/🧵
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