Renato Ostuni
@OstuniLabUltra-Professor at San Raffaele Institute, Milan. Immunity, Cancer, Genomics, Gene Therapy, and Ultra-Running. Here and "there" at https://t.co/vllLM9lUHt
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💥BIG PAPER ALERT💥 So excited to share our latest, out now @Nature! Here, we uncover a spatially confined interplay between subsets of IL-1b+ macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n) nature.com/articles/s4158…
People, the IL-1 pathway is SO RELEVANT in cancer 🔥🔥 IL-1a released from dying tumor cells dampens anti-tumor immunity by recruiting immune suppressive myeloid cells - this limits efficacy of chemo and ICB by Brian Ruffel in @Cancer_Cell cell.com/cancer-cell/fu…
Do you wonder if #regeneration and #tumorigenesis are always linked, or can they be uncoupled to maintain tissue homeostasis? 🤔 Excited to share our latest work published in @Nature, where we explore this fundamental question in the #gut! Link: nature.com/articles/s4158… 🧵👇
Abstract Submission and Online Registration Now Open! 20th Int'l Conference on #Innate #Immunity from May 15-20, 2025 in #Sissi, #Crete, #Greece @KalimeraKriti aegeanconferences.org/src/App/confer… #InnateImmunity
I often say that tissue repair and tumorogenesis are two faces of the same coin. @ejvillablanca &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @Nature nature.com/articles/s4158…
Speaking about IL-1 in cancer, this masterpiece from @MiriamMerad links pathogenic inflammation in the bone marrow to increased tumor development in aging. On a side note - amazing to hear this story in my same session at the latest @sitcancer meeeting science.org/doi/10.1126/sc…
As we showed for PDAC, IL-1b+ Macs are a thing in arthritis - their phenotype driven by PGE2+TNF. The great @ivashkivlab defines the molecular determinants of this synergistic interplay and reveals new ways to target pathogenic inflammation. biorxiv.org/content/10.110…
Another evidence of the pathogenic role of IL-1 in the tumor microenvironment, this time in mediating resistance to immune checkpoint inhibitors
Dr. Filipa Lynce (@FilipaLynce) and colleagues recently published a study showing that T cells instruct immune checkpoint inhibitor therapy resistance in tumors responsive to IL-1 and TNFα Inflammation. pubmed.ncbi.nlm.nih.gov/39404741/
I will not leave, but something real is happening on the other side 🦋
#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper @CellCellPress with @achillebro! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OAL7PXqSL5
This is HUGE - Synthetic receptors that respond to exogenous signals and drive custom responses 🔥 Beautiful paper @Nature by @KoleRoybal and David Baker nature.com/articles/s4158…
Short talk deadline is tomorrow. Join @DrShrutiNaik @OstuniLab and I in Vancouver Feb 2-5th.
📢Ready for an amazing @KeystoneSymp Innate Immune Memory (Feb 2-5, Vancouver)? @DrShrutiNaik @OstuniLab and I look forward to your hottest discoveries - Get your abstract in early for short talk consideration! Deadline in 2 wks pls RT #KSInnateImmune25 keysym.us/KSInnateImmune…
Meetings in Italy never disappoint 🇮🇹 Gala dinner with Maestro Gianluca Podio playing Pino Daniele @EMBO #EMBOSpatial
And now in Rome at @EMBO meeting on Spatial Biology, listening to a legend in the field Xiaowei Zhuang @Harvard @HHMINEWS
#LocationLocationLocation! 💥Our new Feature Review on the regional specialization of the immune response along #airways is out @TrendsImmuno! We discuss anatomical, functional & microbiota factors controlling #innate & #adaptive #immunity! @david_hoytema authors.elsevier.com/a/1jzXg5Eb0Rxn…
Back from an energizing trip to Seoul for #Cytokines2024 + @SeoulNatlUni Amazing science, food, and culture with old and new friends💚 Thanks Keehoon Jung for the invite and the incredible hospitality!
📢Ready for an amazing @KeystoneSymp Innate Immune Memory (Feb 2-5, Vancouver)? @DrShrutiNaik @OstuniLab and I look forward to your hottest discoveries - Get your abstract in early for short talk consideration! Deadline in 2 wks pls RT #KSInnateImmune25 keysym.us/KSInnateImmune…
Much looking to be chairing tomorrow the Cytokines & Myeloid cells (10:40am) & the Lambda Interferon (16:20pm) sessions #Cytokines2024! Such a treat to introduce, among other fantastic scientists, @OstuniLab & @achillebro! #AMentorIsForever💎!@KAI_ImmuneNetw @CytokineSociety
📢The call for the 2025 ACTERIA Early Career Research Prizes awarded by EFIS is open! The awards: - One each in Immunology & Allergology - Cash prize of €30,000 - Possibility of €50,000/year for a 3-year research project 📅 31.12.2024 👉 buff.ly/2PetMkl
Sammy Basso @SammyBasso, one of the most remarkable people to share our world, passed away last night from complications associated with progeria, the ultra-rare ‘rapid aging’ genetic disease Sammy both suffered from and transcended. Sammy realized that a base editing treatment…
📢Ready for the best @KeystoneSymp ever on Innate Immune Memory (Feb 2-5, Vancouver)? @DrShrutiNaik @LabFairfax and I look forward to your hottest discoveries - Get your abstract in early for short talk consideration! pls RT #KSInnateImmune25 keysym.us/KSInnateImmune…
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