Dr. Nicola Luigi Bragazzi (MD, PhD, MPH)
@NicolaBragazziDRP. Global scientist. Infectious disease epidemiologist. Biostatistician
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Galaxies, genes, diseases, languages, and machines
check out our new preprint led by @Charles_Zhou12 and supervised by @MengjieChen6 and me doi.org/10.1101/2024.1… where we present scPrediXcan which integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework
Excited to launch the @HelmholtzMunich Imputation Server, enabling genotype imputation within the EU and beyond. Lots of plans for future development, reference panels and functionality enhancement rdcu.be/d0h3y
Join the talk to hear more about transformers for social science: soc.cuhk.edu.hk/event/nov-14-c…
Highly pathogenic avian influenza A (H5N1) in marine mammals & seabirds in Peru: "We reflect that H5N1 viruses becoming more evolutionary flexible & adapting to mammals in new ways could have global consequences for wildlife, humans, &/or livestock." tinyurl.com/pc68v6x6 by…
Current polygenic risk scores require binning of ancestry groups but we know ancestry is a continuum. Our study led by @Yunfeng_Ruan introduces DiscoDivas, a new generalizable PRS framework across the ancestry spectrum medrxiv.org/content/10.110… @medrxivpreprint @PRSdiversity
And AF3 code is finally released. science.org/content/articl…
DP3 peptide administration inhibits atherosclerosis by preserving the α-helix secondary structures of ApoB100 in a humanized ApoB100 murine model that mimicks the hallmark of human hypercholesterolemia 🔗atherosclerosis-journal.com/article/S0021-… @ciberdem @society_eas @ELS_Cardiology
The first (presumed) human case of H5 avian influenza acquired in Canada has been reported in British Columbia. Details remain limited, with hopes for the individual’s full and swift recovery. Link: tinyurl.com/3k6vnmdz
If Deepmind only releases the model weights, does someone write code around it so the rest of us can run predictions? (Like Colabfold)
Let that sink in / Fatevene una ragione
Hugely honoured to have been selected as the next Director General of @CERN CERN is an incredible organisation where scientists from Europe and beyond have come together to uncover the mysteries of the Universe - incredibly exciting!
REGENIE v4.0 is live!🎉 You can now analyze time-to-event phenotypes, leveraging power gains with case-control phenotypes where time-to-event information is available. github.com/rgcgithub/rege…
Maintaining LDL-C lower than 70mg/dL may be beneficial for cardiovascular protection in advanced CKD patients and a lower LDL-C treatment target may be required as CKD progression 🔗atherosclerosis-journal.com/article/S0021-… @society_eas @ELS_Cardiology #CvPrev
Hw many people with #obesity achieve a BMI <25 using GLP-1 medicines? #OW2024 @ObesitySociety
• Knockout of PPARα does not alter in vivo 🫀 metabolism in either the fed or fasted state of young 🐭 • By 22 months old, PPARα leads to a sign 📈 in 🫀 PDH flux • In PPARα-KO 🐭, there is a sign 📈 in GLUT4 expression 🔗atherosclerosis-journal.com/article/S0021-… @society_eas #CvPrev #EASSoMe
Our new @NatureAging paper: We built 14 "biological clocks" representing the biological age and rate of aging of 14 major body systems using data from 13,000 people of the Human Phenotype Project Key findings: 1. Biological clocks are clinically meaningful: People with higher…
The @UK_biobank is already considered a leading and invaluable data resource for learning about human health. Complementing that is the Our Future Health initiative , which in just 2 years has reached nearly 2 million UK participants (of 5 million planned), and is now by far the…
This is how many people have signed up to #OurFutureHealth to help researchers find new ways to prevent, detect and treat diseases like dementia, cancer, diabetes, heart disease and stroke. Will you join our community and be part of the answer? ourfuturehealth.org.uk
What will be the global impact of GLP-1 drugs? A new @Nature feature nature.com/articles/d4158… by @Sara_Reardon
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