Nicole Chambers, PhD
@NicholinergicPostdoc @UF @LabMoehle @UF_Pharmacology Neuroscience, Movement Disorders, Electrophysiology PhD @binghamtonuniv2 Loves frogs, painting, kayaking she/her 🏳️🌈
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I’m thrilled to share one of my postdoctoral projects in @LabMoehle ! We created a new mouse model of GNAL-linked dystonia which shows overt dystonia-like symptoms and hyperexcitability in striatal SPNs. Thank you to everyone who contributed to this work! biorxiv.org/content/10.110…
In this new preprint, Emily Twedell (PhD student) and colleagues identify a functional role for the inhibitory synapses between striatal projection neurons -- shaping striatal ensembles to promote healthy action selection. biorxiv.org/content/10.110…
If you’re still here at @SfNtweets, come and see posters from @LabMoehle ! This morning Iggy presents electrophysiological and cognitive changes in the PFF model of PD and this afternoon I will present electrophysiology and behavioral data from our Gnal linked dystonia mouse.
Rick's dedication to curing dystonia is inspiring, and he will soon be a published expert in the disease that he and @TylersHope is dedicated to curing.
New lab preprint from the outstanding postdoc @Nicholinergic! Here we report new exciting data from a model of GNAL linked #dystonia that we have created. Most importantly, this model shows overt dystonic motor phenotypes, a first for GNAL linked dystonia (1/N).
Conditional Knockout of Striatal Gnal Produces Dystonia-like Motor Phenotypes biorxiv.org/cgi/content/sh… #biorxiv_neursci
we're just about halfway through #OptoGRC2024 and our community has been as inspiring as it has been transformative -- thank you to everyone from the bottom of my engram-filled heart 🧠 @OferYizhar @bjmarlin @denisejcai @KarlDeisseroth @OptoGRC!
Today we present precise detection of endogenous opioids using genetically encoded biosensors. Multiple early variants have been validated in labs, and we have now optimized, determined, and benchmarked the first-gen opioid sensors for both in vitro and in vivo applications.
New paper out in @NatureNeuro! Collaborating with several labs, we developed genetically encoded biosensors to track opioid pharmacology in the brain & provide powerful new tools for dissecting complex circuit-specific dynamics 🔧🧠 nature.com/articles/s4159…
Excited to have Barbara in the lab now as a SNIP student! She has worked for us for about 2 years now as a volunteer, and will be joining the lab after the summer as a post-baccalaureate fellow.
My conversation with @ScienceMagazine’s @NerdyChristie on 06.19✨ “By celebrating Juneteenth, we are honoring truth.” science.org/content/articl…
if you missed this webinar, it's now online! feel free to reach out with any questions.
@PiantadosiSean and his team developed a deep #brain two-photon calcium imaging approach combined with a novel optogenetic strategy to address which cell types and receptors mediate ensemble receptivity. Learn more in our recent webinar! ➡️ goto.bruker.com/4bZHh0m #neuroscience
Submitted my K99/R00 application today! Thank you to all those at UF and beyond who supported me in writing this application! 👩🏻💻🐊😊🎉
I have been taking papers that seemed interesting from bulletin boards my whole career - this is what they were for in the math department. Are you telling me that people have been hanging up whole-ass papers for any other reason that to invite you read them?
@PiantadosiSean and his team developed a deep #brain two-photon calcium imaging approach combined with a novel optogenetic strategy to address which cell types and receptors mediate ensemble receptivity. Learn more in our recent webinar! ➡️ goto.bruker.com/4bZHh0m #neuroscience
Happy to announce that our paper on PdCO is finally out @naturemethods - check out this great tutorial by the awesome @JWietek:
Against all odds: PdCO, a versatile switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo is finally published @naturemethods nature.com/articles/s4159…
Happy to share this @ahmari_lab work co-led by myself, @DrLizzieManning and @britt_lynn4, with critical help from @vijay_mkn and @DrJamiePierson! We investigated how striatal spiny projection neurons contribute to compulsive grooming in Sapap3-KO mice. nature.com/articles/s4146…
How does the cerebellum distinguish between sensory feedback arising from our own motor actions versus unexpected external perturbations? In our recent paper, we unravel the intricate details of the processes that unfold in the anterior cerebellar vermis nature.com/articles/s4146…
Voluntary headfixation that enables tracking of the same neurons across the lifespan of a rat! Amazing work, @dylanrich! nature.com/articles/s4146…
Excited to share our work in the @mbruchas lab on how endogenous opioids promote goal-directed behavior, funded by @NIDAnews I am currently on the job market and this work will form the basis of my research program. biorxiv.org/content/10.110…
Very excited to share our work with this expert audience next Monday (5/13/2024). Please register at the link below if you are interested in attending!
Excited to announce our upcoming webinar with Dr. Piantadosi, @UW He will describe his use of multiphoton #optogenetics to manipulate optically separable amygdalar valence encoding ensembles in vivo. ➡️ goto.bruker.com/3Wfa386 #neuroscience #brain
Excited to share our study in J Neurosci identifying a new neuron population involved in rhythm generating locomotor network. Congrat to first author @maellebertho, and Vanessa Calderia, @Li16084841, Peter Löw and Lotta Borgius. jneurosci.org/content/44/18/…
Join Me on the @novapbs IG for a Live discussion about the science of generational trauma. What is generational trauma—and why is it important to study? Tune in tomorrow, 12pm EDT @novapbs Instagram. Bring questions!
Join NOVA and neuroscientist Dr. Bianca Jones Marlin (from NOVA's series "Your Brain") for an Instagram Live conversation about the science of generational trauma. What is it and why is it important to study? Tune in on April 25th, 12pm EDT on NOVA'S Instagram (@novapbs).
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