Nadia Dinunno
@NadiaMD13M3 MD-PhD @ PSU COM image processing, neurobiology, infectious disease
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Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x tinyurl.com/c7szhtfa
A comprehensive review in @BloodJournal on risk stratification/scoring in MPNs ashpublications.org/blood/article/…
Published in @ScienceMagazine: "Direct optical measurement of intramolecular distances with angstrom precision" (Sahl et al.) science.org/doi/10.1126/sc… @mpi_nat @mpi_mr_hd #Optics #Imaging #Microscopy #MINFLUX #Fluorescence
How To Choose a Good Scientific Problem @CellCellPress sciencedirect.com/science/articl…
Getting started with pre-processing in #cryoEM? Check out our updated #CryoSPARC guide pages on motion correction! We cover the theory behind motion correction, differences between jobs and how the methods behind Patch Motion and other algorithms work! guide.cryosparc.com/processing-dat…
The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have…
In 2003, this year’s chemistry laureate David Baker succeeded in designing a new protein that was unlike any other protein. This was the first step in something that can only be described as an extraordinary development. A few of the many spectacular proteins created in Baker’s…
Continuous probability distributions "converted "into discrete distributions when using finite precision arithmetic in critical ML applications like differential privacy, etc Gaussian distributions converted as ***lattice Gaussians***: Maximum Entropy distributions
Structural basis of ligand recognition and activation of the histamine receptor family | Nat Commun doi.org/10.1038/s41467…
Using cryo-EM, the authors revealed structures of ESCRT-III superfamily member PspA and the molecular basis of structural plasticity that enables assembly modulations by the addition of nucleotides and targeted mutations. nature.com/articles/s4159…
Our review on Language in Brains, Minds, and Machines (with @Nancy_Kanwisher @ev_fedorenko) is now officially published and the volume is OPEN access! annualreviews.org/content/journa…
1/ Really excited to share: Language in Brains, Minds, and Machines w @Nancy_Kanwisher @ev_fedorenko @AnnualReviews We survey the insights that language models (LMs) provide on the question of how language is represented and processed in the human brain. rb.gy/8afztv
NYSBC researchers have created a 'cryoEM calibration standard, a mixture of macromolecules, to provide multiple reference points within a single experiment: biorxiv.org/content/10.110…
We are standing on the cusp of a new era of biology, where the integration of multimodal structural datasets with multiscale physics-based simulation will enable the development of visible, virtual cells. My dream for #COVIDisAirborne @kprather88 & the molecular basis of life…
Postdoctoral position in computational biophysics, machine learning, and structural biology is open! Please see details in the attached.
Come and join this amazing group of scientists to work at the cutting edge of structural biology of telomeric complexes. The LMB is a highly collaborative place. Please share!
We have an excellent #postdoc position to work with @KellyTHD_Nguyen, focusing on the molecular mechanism of telomere maintenance in eukaryotic cells using biochemical & structural approaches. nature.com/naturecareers/… Apply by 21 AUG #PostdocJobs #ScienceJobs
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