MedChem & ONCO
@MedChem314Medicinal Chemistry-Drug Discovery-Oncology-Chem Bio, Emmanuel Bertounesque, PhD, Post-Doc Penn, HDR, Q-PR, Oncology Med Chem Res, Institut Curie 1988-2013.
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We are delighted to share our recent article on "A Cascade Synthesis of Furo‐Pyrrolo‐Pyridines via Pd(II)‐Catalyzed Dual N−H/C Annulative‐cyclization"published in @ChemEurope Heartiest congratulation to @HirendraDhara @IITGuwahati @serbonline @IndiaDST …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…
The #SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage cell.com/cell-host-micr… just published @cellhostmicrobe @erturklab open-access
The universe can have three possible geometries: closed, open, or flat, determined by the density parameter Ω₀. A closed universe ( Ω₀ > 1) is finite, with curved space that loops back on itself. Open (Ω₀< 1) and flat universes (Ω₀ =1) are infinite, with straight paths…
Researchers have shown that an air-stable rhenium aqua alkylidyne complex can mediate alkyne metathesis at room temperature. chemistryworld.com/news/air-stabl…
This was hands down the hardest system I worked on during my PhD. Huge thanks to Yohan and Lotte (who are way too cool for Twitter) for making it fun! We are excited to share that we proved coupled helicene inversion to the motor's rotation. Check it out 🔗👇
Coming in HOT! Our most recent @angew_chem 🔥 paper. We coupled the helicene inversion to the rotation of our molecular motor. Follow the link to see more of the #OpenAccess work led by Yohan Gisbert with the help Of @MarcoOvalleMA and Lotte Stindt. onlinelibrary.wiley.com/doi/10.1002/an…
Now out in @J_A_C_S : A mechanistic exploration of aminocatalyzed [6 + 4] and [10 + 6] cycloadditions and the novel Favorskii-like rearrangements they enable. Congratulations to Casper and the team!🎉 | #AUChemistry pubs.acs.org/doi/10.1021/ja…
#NatureNews New, Effective CAR-T Strategy @Nature IL-15 increases the expansion, intratumoural survival and antitumour activity of GPC3 CAR T cells in patients. #Science #News #CART #Oncology #Cancer #MedEd #MedX
While chemists have synthesized close to 140 million compounds, there are an estimated 10^60 possible compounds in the universe! That's a lot of undiscovered chemistry! Chemists play a crucial role in unlocking this vast chemical space. #SyntheticChemistry #Discovery
It is with great sadness that i learned about passing of Hans Paulsen, one of the fathers of carbohydrate chemistry, the way we know it today. This is a huge loss for our community #glycotime @acs_carb chemistryviews.org/hans-paulsen-1…
Stereoselective Glycosylation for 1,2-cis-Aminoglycoside Assembly by Cooperative Atom Transfer Catalysis | JACS @BrandeisU @BrandeisScience @TotalSyntheses #Stereoselective #Glycosylation #AminoGlycoside #Fe #AtomTransfer #Catalysis pubs.acs.org/doi/10.1021/ja…
Nothing beats a good, well worn collection of Synthetic Design books!
Excited to share our new publication on photocatalysis! In @angew_chem we describe benzylic C-H phosphonylation using dual copper and photocatalysis. Great work done by @HenghuiLi and Yuwen Liu! Link: onlinelibrary.wiley.com/doi/10.1002/an…
Sometime simple solutions are best: Have a look at the last work of Emma @EmmaGabRobert on the synthesis of N-Heterocycle substituted cyclobutanes via Michael addition now available @ChemEurJ …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…
We're incredibly proud to say that our review of Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis is now online and open access at @ACSChemRev! Congrats to the team for this labor of love (and data!) pubs.acs.org/doi/10.1021/ac…
A drug approved for heart failure can also kill aggressive ovarian cancer cells and resensitizes relapsed tumors to chemotherapy in mice, pointing to a potential treatment avenue for this deadly gynecological cancer. @scisignal bit.ly/40YLKO2
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas science.org/doi/10.1126/sc…
The Baker Lab @UWProteinDesign recently hosted this powerful webinar on computational protein design. Take a journey through the history of this groundbreaking field, guided by some of the greats! youtube.com/live/BuJGTn7Oh…
My main PhD project has been published lately as Very Important Publication on ASC! 🎉 In this work we exploit carbon monoxide for the direct synthesis of a novel class of α,β‐Unsaturated γ‐Lactams. The article is now available in open access: onlinelibrary.wiley.com/doi/10.1002/ad…
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