@MarioniLab Profile picture

MarioniLab

@MarioniLab

The official Twitter account of the John Marioni Lab - not John himself. Single cells, statistics and computational biology.

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MarioniLab Reposted

Are you missing cells and cell types in your single-cell multiome experiments @10xGenomics? Check out EmptyDropsMultiome @MarioniLab


MarioniLab Reposted

Join our faculty: ebi.ac.uk/research/groups - our 9-year tenure nurtures our group leaders to go on to do great things: @VirginieUhlmann @MoritzGerstung @OliverStegle @MarioniLab @teichlab @pedrobeltrao


MarioniLab Reposted

Mark you calendars! Next Cambridge Computational Oncology Meeting is May 5 at the EBI in Hinxton. Speakers: Hillary Elrick @hbelrick , Alex Gutteridge @ruggedtextile and Peter Campbell

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MarioniLab Reposted

Happy to present my recent work - a cluster-free method for DE testing, leveraging overlapping neighbourhoods in the graph representation of sc-data (aka miloDE): biorxiv.org/content/10.110… . A little thread below describes the motivation and suggestions on interpreting the results.


MarioniLab Reposted

The developing human lung has been mapped in unprecedented detail, identifying 144 cell states in the early stages of life, and uncovering new links between developmental cells and lung cancer. ebi.ac.uk/about/news/res…

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MarioniLab Reposted

Excited to share @CarineStapel and my #singlecell #singleorganoid time course of #gastruloid development. We reveal substantial inter-organoid heterogeneity, and show why understanding it is critical in #organoid #perturbation experiments. A #tweetorial (1/18)

Inter-gastruloid heterogeneity revealed by single cell transcriptomics time course: implications for organoid based perturbation studies biorxiv.org/cgi/content/sh… #bioRxiv



MarioniLab Reposted

AlphaFold DB will boldly go where no scientist has gone before. With over 200 million protein structure predictions added to the database, AlphaFold DB now gives users open access to a 3D protein universe. #AlphaFold @DeepMind ebi.ac.uk/about/news/tec…

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A magical week at the Marioni Lab retreat - a blessing of (purple) unicorns indeed and many (uni)corny jokes

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MarioniLab Reposted

John Marioni has been elected as a new Fellow to the @acmedsci 👏 in recognition of his remarkable contributions to biomedical science and the generation of new knowledge to improve the health of people everywhere. #AMSFellows2022

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Congratulations to our 60 new Fellows announced today Find out more about these outstanding biomedical and health scientists and see the full list on our website: ow.ly/J2UV50J146j #AMSFellows2022

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We're hiring! Looking for an enthuastic postdoc to join the team and work with single-cell genomics data to construct and compare senescence trajectories for cells. Deadline 22nd Feb embl.org/jobs/position/…


MarioniLab Reposted

The new @EMBL Programme has launched! We're proud to be a part of @EMBL and we're looking forward to contributing our #bioinformatics expertise to this exciting new scientific programme that ushers in a new era in the life sciences.

EMBL embarks on a new era of molecular biology. EMBL research will expand to study life in context – from molecules to ecosystems. Broad in scope, our next programme encompasses fundamental research, services & multidisciplinary collaboration. embl.org/news/lab-matte…



MarioniLab Reposted

For a lay summary of our new method to study #transposableelement expression with long read sequencing in single cells please read this post

A study led by @RBerrens looks at a new method for studying the role of transposable elements in genetic information - gatescambridge.org/about/news/new… @GatesAlumni @Cambridge_Uni @Trinity1546 @Cambridge_SBS



MarioniLab Reposted

Very happy that our single CELl LOng read RNA sequencing (CELLO-seq) method for locus-specific #TransposableElement expression is out in @NatureBiotech today! Find the paper here: nature.com/articles/s4158… 1/n


MarioniLab Reposted

Congratulations to @Blavatnikawards 🇬🇧 Finalist 🏅 Finalist in Life Sciences Dr. John Marioni @MarioniLab @emblebi @CRUK_CI #Blavatnik2021 bit.nyas.org/3n0x0Yb #computationalbiology #RNAtranscription

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MarioniLab Reposted

What are the ripples of making data #openaccess? A recent independent report quantified these efforts to explore the role of #opendata in the life sciences today. #OAweek #opendata ebi.ac.uk/about/our-impa…

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MarioniLab Reposted

Differential abundance testing on single-cell data using k-nearest neighbor graphs go.nature.com/2Y69iSH

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Still time to apply for our new postdoc position using computational approaches to study developmental trajectories across species. Deadline 19th September jobs.cam.ac.uk/job/31028/


MarioniLab Reposted

NEW POST: We (virtually) sat down with John Marioni, new collaborator on the Cancer Grand Challenges IMAXT programme @emblebi @CRUK_CI @sangerinstitute to find out more about his work and what excites him about the project. Read more - bit.ly/3svUnMP


We're looking for a new postdoc in the Marioni group - a two year position to work on developmental trajectories across species using single-cell approaches and data integration methods jobs.cam.ac.uk/job/31028/


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