MV Mazzuoli
@MVMazzuoliPost doc @DMF_UNIL in @JWVeening lab | Ph.D, @InstitutPasteur @Microbio_IP
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Proud to share my latest PhD work! We found that in GBS, CRISPR-Cas9 immunity is integrated within the virulence regulatory network. This co-regulation, mediated by CovR—the major regulator of virulence—could enhance the immune repertoire during infection. biorxiv.org/content/10.110…
I had some help 🎶 Teamwork makes the dream work! Checkout our latest preprint spearheaded by Jessica Burnier in a great collab with the labs of Waldemar Vollmer, @victornizet & Malcolm Winkler biorxiv.org/content/10.110…
Great work from @Bevika2 in our lab - CRISPRi-seq hits again!
Checkout @Bevika2 preprint! She used CRISPRi-seq to determine antibiotic-stress signatures, specifically of pneumococci treated with fluoroquinolone antibiotics. It's a really powerful approach revealing a surprising antibiotic combination therapy. 1/9 biorxiv.org/content/10.110…
Excited to share that our paper is now out in @NatureMicrobiol! We characterize a positive mechanism for Z ring placement in S. aureus governed by the proteins PcdA/DivIVA, and its implication during infection in a mouse model nature.com/articles/s4156…
Virulence regulates and boosts CRISPR-Cas9 immunity in Group B Streptococcus ✍️Adeline Pastuszka, @MVMazzuoli, Philippe Lanotte, Arnaud Firon and colleagues @INRAE_France @institutpasteur biorxiv.org/content/10.110…
Do you use D39V, TIGR4, EF3030, BHN418, or another pneumococcal strain in your research? Easily browse their genome on PneumoBrowse 2 pneumobrowse2.veeninglab.com! Now out in shiny PDF in Nucleic Acids Research! Do you have any feedback? Please let us know! academic.oup.com/nar/advance-ar…
Happy to announce PneumoBrowse 2! Access it here: pneumobrowse2.veeninglab.com and read the preprint here: biorxiv.org/content/10.110…
Exciting approach to decipher two component system networks and their interactions in Streptococcus agalactiae - Arnsud Firon, @MVMazzuoli et al.| Nature Communications nature.com/articles/s4146…
Thrilled to have contributed to this innovative approach of costitutively activating TCS sensors to decode complex regulatory networks. Exciting insights into GBS host-pathogen interactions—definitely a must-read! nature.com/articles/s4146…
I am please to announce that @Navarro_PaulaP and I are organizing this year's @DMF_UNIL Impromptu Symposium on Bacterial Cell Biology. We are looking forward to an exciting day of science with a fantastic speaker lineup 🧫🦠🧬🔬❄️ Registration is open (using QR codes).
Excited to share this preprint! Our multiscale approach has finally shed light on the essential roles of the structural protein HU in pneumococcal nucleoid dynamics. Thanks to all co-authors for their contribution to this collaborative work.
Awesome work by @MVMazzuoli Renske van Raaphorst, Louise, Florian in collaboration with the team of @rkoszul Revealing a role for HU in promoting long-range chromosome interactions. biorxiv.org/content/10.110…
Yesterday again a fantastic DMF Science day organized by students and post-docs with great talks by @AHarms485 @AVettiger @Navarro_PaulaP and exciting posters and networking! Such a buzzing and vibrant group of talent!
Grateful to have been able to share my work at the Swiss Society for Microbiology & Infectious diseases Joint Annual Meeting and represent the @JWVeening lab!
Current, former, incoming and associated (Victor) lab members at the #GRCStrepBio24 #strepyourgameup #GRCstrep #StrepGRC
OUT NOW 👉 A dynamic subpopulation of CRISPR–Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage @marie_stoltzfus @jwmodell nature.com/articles/s4156…
Happy that the work has now been published @mbiojournal! Many thanks again to @victornizet for hosting me, @elisabetbjanes Alex, @AxelJans @PaddyGibson2 @afonsbravo Samira, @jonbakerlab @andrewjvarble & @snsf_ch scientific exchange grant for enabling! journals.asm.org/doi/10.1128/mb…
You can now read what I have been up to @victornizet @UCSanDiego! Very grateful for this great experience & Victor's continued mentorship, my colleagues @DMF_UNIL for taking over my duties @unil and @snsf_ch for making this scientific exchange possible! biorxiv.org/content/10.110…
Find out how we developed a Prime editing tool in which cells either make a precise genetic change or die, ensuring that only successfully edited cells survive. Given its high efficiency and precision, the applications it offers are endless! 👇🏼
This is a game changer for how we do genetics in our lab! Fantastic effort by Monica, @MVMazzuoli @AxelJans Anne-Stephanie & @liuxuescience 1/n biorxiv.org/content/10.110…
Our first genome-wide CRISPRi-seq genetic screen in Staphylococcus aureus where we identify essential genes and pathways involved in tolerance to the antibiotic dalbavancin. Great work by @liuxuescience @vincentdebakker in collaboration with @Morten3891 👏 journals.asm.org/doi/10.1128/ms…
The @NCCR_AntiResist consortium in all its glory😀 🦠👨🔬👩🔬 #TransformingAntimicrobialResearch
Join us for an exciting DMF seminar this Friday by @lab_reyes on DNA replication in live cells at 12:15h in the Biophore!
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