Raleigh M. Linville
@LinvilleRaleighHeiman Lab postdoc @MIT_Picower. PhD @JHUBME. Studying: #bloodbrainbarrier #addiction #neurodegeneration #striatum 🧠🔬🏳️🌈(he/him)
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🤩 My NINDS F32 fellowship was funded! Exciting news culminating the first year of my #postdoc in the Heiman Lab @MIT_Picower
What geneticists fear the most: The Cambridge Plot.
Very excited to share our pre-print and my thesis work on the postnatal development of astrocyte regional heterogeneity, which includes an integrated dataset of >1.4 million single nuclei transcriptomes in mouse and marmoset brains (now available online)! biorxiv.org/content/10.110…
So excited to share the PhD work 👶 of Laurence @cLAUdin5_ exploring how #pericyte function modulate 🧠 #stress responses 🐭 & human #depression Behaviors, sex differences, new viruses, 🔬 morpho, ephys, 🩸 sequencing, a colossal effort with help of many! researchsquare.com/article/rs-506…
This is the best news of the week! ‘Gamechanger’ HIV prevention drug to be made available cheaply in 120 countries! A twice year injection that showed 100% success in protecting against HIV infection! theguardian.com/global-develop…
Excited to join @WhiteheadInst community! I’m grateful to @manoliskellis and @MITEECS for my graduate training and supporting my journey here. My lab will study the complexity of cell-cell communication and explore its broader implications across various biological scales.
Whitehead Institute appoints Na Sun as the inaugural AI Fellow within the Whitehead Fellows Program. In this role, Na will develop computational methods to decipher complex cell-cell communication in the brain. Welcome, Na! wi.mit.edu/news/computati…
So excited to organize the next Brain Barriers meeting @CSHL with @SiegenthalerLab @AyalBen & Joy Zuchero 🧠 mark your calendar April 8-12, 2025 and a teaser with our fabulous keynote and session chairs 👇 meetings.cshl.edu/meetings.aspx?…
Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells @NatureNeuro nature.com/articles/s4159…
Overlooked poor-quality patient samples in sequencing data impair reproducibility of published clinically relevant datasets genomebiology.biomedcentral.com/articles/10.11…
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain | Nature Communications nature.com/articles/s4146…
New paper out in @NatureNeuro! Collaborating with several labs, we developed genetically encoded biosensors to track opioid pharmacology in the brain & provide powerful new tools for dissecting complex circuit-specific dynamics 🔧🧠 nature.com/articles/s4159…
I am very happy to share that my first-author paper from the PhD work is now published in Nature: nature.com/articles/s4158…
This is HUGE for HIV prevention! An injection of #Lenacapavir given just twice a year demonstrated 100% efficacy for HIV prevention. An independent data monitoring committee recommended the company stop the blinded-phase trial and offer the drug to all participants.
Researchers in the trenches of the fight against HIV got a rare piece of exciting news this week: Results from a large clinical trial in Africa showed that a twice-yearly injection of a new antiviral drug gave young women total protection from the virus. nyti.ms/4csgIka
I am heartbroken that another cyclist was killed by a truck in Cambridge this morning. My thoughts go out to their loved ones. It’s another tragic reminder that we cannot go backward on bike safety; we must continue doing more at every level of government. cambridgeday.com/2024/06/21/sec…
Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction | Nature Communications nature.com/articles/s4146…
Very excited to share this new preprint led by the super talented @klbrida We started by asking what marks drug-activated ensembles and stumbled onto a surprising answer that identified a key regulator of neuronal excitability and reward. A brief 🧵... biorxiv.org/content/10.110…
Excited to share our #SingleCell dissection of #Schizophrenia, out in @ScienceMagazine today, reporting 470k cells in 27 cell types across 140 individuals from 2 cohorts, revealing key insights on #ExcitatoryNeurons, #NeuroDevelopment, #Synapses, #1Cmetabolism, #Genetics,…
Our #SingleCell dissection of #Schizophrenia genes/pathways, a new #TranscriptionalResilience cell type, target genes at #GWAS loci, and upstream #MasterRegulators is out @medRxivPreprint #PsychENCODE #BradRuzicka @Mohammadi_PhD #JoseDavila @NIMHgov medrxiv.org/content/10.110…
Our paper "Exercise to Prevent Accelerated Vascular Aging in People Living With HIV" is now published in @CircRes 👇 ahajournals.org/doi/10.1161/CI… It was fun writing and learning with these experts @AusRob_PhD @merrylindseyphd @phdgprotein86 @NathanASmith1 Thanks for including me!
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