Lienka
@Lienka8Neuroscience, stress, chorizo, morcilla y empanada. Neuroscientist.
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Fantastic summary figure of molecular mechanisms of Parkinson's by Shaheen and colleagues in @Nature Parkinson's. MicroRNAs (miRNAs) represent small non-coding molecules that regulate gene expression. They bind target messenger RNA (mRNA) molecules and promote degradation. They…
AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer’s disease mice: Molecular Therapy cell.com/molecular-ther…
No solo tu chaqueta, tus pantalones 🫵👖 también son demasiado pequeños. 🤏
we should not think of the state as a barrier to growth, but rather a stimulator and partner. the gov can help build important partnerships between universities, private enterprises, and investors. and help those thrown out of work bc of disruptive innovations.
Understanding the difference between Standard Deviation (SD) and Standard Error (SE) is crucial for accurate data interpretation. SD measures the variability within your data, indicating how spread out the individual data points are from the mean. In contrast, SE measures the…
EMBO Astrocyte Workshop - this will be a 'stellar' meeting. Join us!
A 2023 Review in Science Translational Medicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia. Learn more: bit.ly/4esssnw #ScienceMagArchives
A third study showing the OL contribution to Aβ burden. The team showed -30% Aβ plaque amount, upregulated myelin genes in oligodendrocytes (OLs), and many new findings that expand our knowledge on amyloidogenic processing in OLs. …arneurodegeneration.biomedcentral.com/articles/10.11…
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia | EMBO Molecular Medicine embopress.org/doi/full/10.10…
New @ScienceMagazine Evo, a large language of life (LLLM) genomic foundation model, predicting & generating tasks from molecular to genomic scale science.org/doi/10.1126/sc… @pdhsu @BrianHie @arcinstitute @Stanford
Integration of CSF proteomics, metabolomics and genetics identify causal and druggable targets for #Alzheimers disease The Cruchaga lab published two side-to-side manuscripts in Nature genetics (nature.com/articles/s4158…; nature.com/articles/s4158…). @WUADRC @WashUNeurology
It is a really jarring moment to be a historian. To know what might be coming is alarming. To realize that no one around you sees it or acknowledges it is a weird place to be in. Its like time traveling without time traveling. 1/8
Redox regulation, protein S-nitrosylation, and synapse loss in Alzheimer’s and related dementias: @NeuroCellPress cell.com/neuron/fulltex…
The apparent election victory of Donald Trump, has consequences for the world, that I'm sure, very few people, have ever thought of. The world has just been sent, in an incredibly dangerous direction. 1/🧵
the education gap has never been clearer and i mean that as non condescendingly as possible - we literally are getting dumber as a society. no critical thinking skills, reading comprehension & attention spans are at an all time low. it feels hopeless at times
All the takes are correct and yet they also miss the point. Yes, it was insane for the Democrats to think they could win by running a soulless candidate, without a shred of progressive policy vision, pursuing endorsements from neocon war-hawks everybody hates, while arming and…
EL PROBLEMA NO ES SOLO DONALD TRUMP Donald Trump roza la presidencia de EEUU. A sus votantes no les importa que sea racista, xenófobo, misógino, autoritario, machista y un delincuente convicto. De hecho, le han votado por ese motivo. La América blanca y protestante no soporta la…
I thought this would hurt more than 2016 but it doesn't. That was a shock. This is just confirmation. We now know that 2016 wasn't a fluke or an aberration, that this is what the majority wants: whiteness, patriarchy, nationalism, hatred, nihilism. Whether I want to spend the…
A new state-of-the science review on #Parkinson's disease nature.com/articles/s4158… @NatRevNeuro @angelo_antonini @AronEmmi
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model: Cell Stem Cell cell.com/cell-stem-cell…
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