@FranMartinezGr Profile picture

Francisco Martínez

@FranMartinezGr

PhD, Clinical Geneticist

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De novo missense variants in the PP2A regulatory subunit PPP2R2B in a neurodevelopmental syndrome: potential links to mitochondrial dynamics and spinocerebellar ataxias #RareDisease #Genetics #morbidgene academic.oup.com/hmg/advance-ar…

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AMOTL1-Associated Multiple Congenital Anomalies (Craniofaciocardiohepatic Syndrome, CFCHS): A Novel Clinical Spectrum Including Craniofacial, Heart and Liver Abnormalities #RareDisease #Genetics #morbidgene onlinelibrary.wiley.com/doi/10.1111/cg…


Variants in NR6A1 cause a novel oculo-vertebral-renal (OVR) syndrome #RareDisease #Genetics #morbidgene medrxiv.org/content/10.110…


Upregulation vs. loss of function of NTRK2 in 44 affected individuals leads to two distinct neurodevelopmental disorders #RareDisease #Genetics sciencedirect.com/science/articl…

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Coding and non-coding variants in the ciliopathy gene CFAP410 cause early-onset non-syndromic retinal degeneration #RareDisease #Genetics nature.com/articles/s4152…

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Biallelic variants in CCN2 underlie an autosomal recessive kyphomelic dysplasia #RareDisease #Genetics #morbidgene nature.com/articles/s4143…

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Homozygous synonymous FAM111A variant underlies an autosomal recessive form of Kenny-Caffey syndrome #RareDisease #Genetics #morbidgene nature.com/articles/s1003…

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Biallelic loss-of-function variants in GON4L cause microcephaly and brain structure abnormalities #RareDisease #Genetics #morbidgene nature.com/articles/s4152…

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CUL3-Related Neurodevelopmental Disorder: Clinical Phenotype of 20 New Individuals and Identification of a Potential Phenotype-Associated Episignature #RareDisease #Genetics cell.com/hgg-advances/f…

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Loss of DOT1L function disrupts neuronal transcription, animal behavior, and leads to a novel neurodevelopmental disorder #RareDisease #Genetics #morbidgene medrxiv.org/content/10.110…

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RLIM-specific activity reporters define variant pathogenicity in Tonne-Kalscheuer syndrome. #RareDisease #Genetics cell.com/hgg-advances/f…

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Epileptic encephalopathy linked to a DALRD3 missense variant that impairs tRNA modification #RareDisease #Genetics #morbidgene cell.com/hgg-advances/f…

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Homozygous variants in WDR83OS lead to a neurodevelopmental disorder with hypercholanemia #RareDisease #Genetics #morbidgene cell.com/ajhg/fulltext/…

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Biallelic GGGCC repeat expansion leading to NAXE-related mitochondrial encephalopathy #RareDisease #Genetics link.springer.com/article/10.100…

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Biallelic germline DDX41 variants in a patient with bone dysplasia, ichthyosis, and dysmorphic features #RareDisease #Genetics #morbidgene link.springer.com/article/10.100…

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Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK) #RareDisease #Genetics sciencedirect.com/science/articl…


Francisco Martínez Reposted

🔝Descubrimiento de deleciones en un gen de ARN largo no codificante- lncRNA (𝘊𝘏𝘈𝘚𝘌𝘙𝘙) como causa de un trastorno del neurodesarrollo humano. Vía @NEJM Importante para las #EERR no diagnosticadas 🍀 avanzar en la investigación del genoma no codificante! 🧬

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