Durga Prasanna Misra
@DurgaPrasannaM1Rheumatologist (Addl Prof, SGPGIMS),Epidemiologist.Vasc Rheum, #Takayasu, Executive Editor@ijrheum, Deputy Editor@JRCPE, AE@Int J Rheum Dis, EC Member(IRA)
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#ACR24 SELECT GCA trial Upadacatinib in GCA Met primary end point - sustained remission Week 12 to week 52 #ACRambassador @ACRheum
The assessment of prednisone taper in remission trial. ➡️Method Plenary session. #ACR24
🇯🇵🇺🇸JCR-ACR Scientific Session @JCRheum @ACRheum 📌Vascular Damage in Autoimmunity ✅Type I IFN -> antiangiogenic -> vascular damage ✅Low-Density Granulocytes in #SLE 👉NET formation⬆️ 👉Trapped in blood vessel networks ➡️Vascular damage —Mariana Kaplan #ACRambassador
🚨 Highlight from #ACR24 Plenary Session 🚨 @DrPeterMerkel presented findings from the SELECT-GCA Phase 3 trial on the efficacy of Upadacitinib (UPA) in patients with Giant Cell Arteritis (GCA). A game-changer in steroid-sparing therapy for GCA! #ACRAmbassador @ACRheum
Vasculitis people rock!@Amansharmapgi @chengappa_kg
What a trial well done...the vasculitis people are doing way better than lupus or scleroderma people
Treatment of Neurosarcoidosis #ACRReview #ACR2024 #ACR24 #ACR #Rheumatology @rheum_cat
SELECT-GCA Trial results show UPA 15 mg + 26-week GC taper leads to 46% sustained remission vs. 29% with placebo + 52-week taper (P=.0019). UPA15 reduced GC use (median 1615mg vs. 2882mg, P<.0001) and improved fatigue scores. Key finding: UPA15 combined with a 26-week GC…
💊 The TAPIR Trial (Assessment of Prednisone In Remission) tackles the big question in GPA care: Does low-dose glucocorticoid (GC) maintenance (5 mg/day) prevent relapse better than stopping GC entirely (0 mg/day)? @DrPeterMerkel #ACRAmbassador #ACR24 ✨
Langford et al. Abatacept NOT effective in GPA in ABROGATE RCT. 65 patients. Relapse/worsening in 62% vs 68%. No difference in any secondary end-point. @RheumNow #ACR24 Abstr#0823 acrabstracts.org/abstract/a-ran…
Its all good data until your patient experiences diarrhoea. This is least considered while universally advocating colchicine!
❓hsCRP or LDL? Better CV risk marker?🤔 🌟Wonderful session on CV risk and role of #Colchicine 🌟Data says: ✅ ⬆️hsCRP has more CV risk than LDL ✅ If hsCRP <2 mg/L, risk same even if LDL >70 mg/dL Also, ❓Are you using Colchicine enough in your practice? #ACR24 #ACRambassador
The TAPIR Trial on GPA shows higher (15.5%) relapse in the 0 mg prednisone arm vs. 4.2% in the 5 mg arm (OR 4.22), but does not impact PROs. Key finding: benefit of 5 mg/day seen only in non-rituximab regimens (20% vs. 2.6%, OR 9.50). Abstr#0774 Plenary 1 @RheumNow #ACR24…
Fixed it for you Jacques... "How can he say Max Verstappen is the greatest of all time? He had a great season when he couldn't beat Lewis for his first championship without the RD inventing new rules... then he's had easy ones with lots of scandals" #F1 #F1xed
Jacques Villeneuve on Jeremy Clarkson putting Max Verstappen as the F1 GOAT: "How can he say Max Verstappen is the greatest of all time? He had a great season when he beat Lewis [Hamilton] for his first championship... then he's had easy ones." planetf1.com/news/jacques-v…
#ACR24 IL 17 has multiple roles Inflammation Thrombosis Cartilage damage Erosion.
#ACR24 supervised weight and exercise training has beneficial role in RA Remote monitoring is possible #ACRamb
🔬 Session 0771: Arid5b & RA Fibroblasts Arid5b is a key transcription factor shifting synovial fibroblasts from inflammatory to invasive phenotypes via epigenetic regulation. This groundbreaking study reveals a dual role for Arid5b in rheumatoid arthritis. #ACRambassador
Major update in tx for GCA beyond Toci SELECT-GCA showed upadacitinib 15mg daily achieving higher rates of remission with SHORTER (26wk) steroid use compared to placebo (52wk) No significant adverse safety signal w JAKi including MACE/malignancy @RheumNow #ACR24 Abstract 0770
A systematic review highlights the impact of glucocorticoids (GC) during pregnancy and lactation. Increased risks of preterm birth were noted with GC exposure, advocating for minimized doses and pregnancy-compatible treatments. Encouragingly, low levels of GC found in breast milk…
TAPIR just out at ACR comparing AAV patients with 5 mg vs. 0 mg maintenance prednisone. At M6, 5 mg offers less relapse (4.2% vs. 15.5%), almost all minor. Relapse-wise, benefit of 5 mg prednisone highest in pts without RTX maintenance (2.6% vs. 20.0%) @DrPeterMerkel @ACRheum
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