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Imagine walking around with all ths ability, and the world telling you , No.watching ppl half ur intelligence being promoted past you not because u r not able , but because nobody thinks you deserve it .# my life story . # Becoming
Wow!!!!!! Metformin has a 30% reduction in asthma!!!! GLP1 has 40%!!!! BETTER than any known treatment in the history of asthma!!! and EVEN BETTER it works INSTANTANAOUSLY with one pill! (sarcasm intended)
Metformin was associated with a lower rate of asthma attacks, with further reductions with the use of GLP-1RA. ja.ma/3UQckFp
CLEAR SYNERGY: Use of colchicine post AMI largest trial of colchicine in AMI Keys: ❗️High use of conventional therapy with high statin use and P2Y12 ❗️Half patients had multivessel disease and staged pci Results: ✅Decreased CRP ❌MACE (death, MI, stroke) was not different…
EPIC-CAD: In a multicenter, randomized trial, edoxaban monotherapy led to a lower risk of net clinical adverse events at 12 months than dual antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease. nej.md/3Z1D1d3 #ESCardio
Current US FDA/Expert Consensus Guidance 👉SGLT2i contraindicated in patients with baseline eGFR< 20. 👉Sacubitril/valsartan contraindicated in patients with baseline eGFR< 30 and should be discontinued if eGFR falls below 30. 👉MRA contraindicated in patients with baseline…
🫘It’s all about Nephrology 🤩 in @NEJM this week 🎯Autoantibodies against nephrin in MCD/FSGS 🎯Felzartamab in kidney transplant antibody mediated rejection 🎯And Semaglutide in CKD
BIG: #Tirzepatide, which is sold commercially as #Mounjaro or #Zepbound, succeeded in a Phase 2 test as a treatment for the fatty liver disease #MASH: 74% of treated patients were free of MASH after 52 weeks vs 13% of the placebo group. statnews.com/2024/02/06/eli… via @statnews
The addition of subcutaneous daratumumab to bortezomib, lenalidomide, and dexamethasone therapy and to lenalidomide maintenance therapy had a significant benefit on progression-free survival among patients with multiple myeloma. Full PERSEUS trial results: nej.md/3Nm3j33
The combination of the G12C-specific KRAS inhibitor sotorasib + the anti-EGFR antibody panitumumab was superior to standard care in patients with chemorefractory KRAS-mutated colorectal cancer. Full CodeBreaK 300 trial results: nej.md/3M8Qw3k #Oncology
In this phase 3, randomized trial in youth with newly diagnosed type 1 diabetes, two courses of teplizumab, a humanized monoclonal antibody to CD3, preserved β-cell function. Full PROTECT trial results: nej.md/45zxmL0
Selpercatinib — a first-in-class, highly selective, potent, brain-penetrant, oral RET kinase inhibitor — has shown promise for the treatment of RET-mutant medullary thyroid cancer in nonrandomized studies. Full LIBRETTO-531 trial Research Summary: nej.md/3M55VS7
Sibeprenlimab in IgA Neph 🔥🔥🆕 🧬Sibeprenlimab-humanised monoclonal IgG2 Ab-Blocks APRIL ⬇️galactose-deficient IgA1 📇 12 months i.v sibeprenlimab in Bx confirmed IgA Neph significantly greater ⬇️ in proteinuria than placebo @NEJM
🔥Must know recent FDA✅drugs nephro🆕 ✅Daprodustat-oral HIF-PHI anemia in CKD ✅Pegunigalsidase alpha-Fabry ✅Rivfloza-RNA interference- 1 hyperoxaluria ✅Sparsentan-IgA Neph ✅Letermovir-CMV Ds in kid Tx ✅Tenapanor-⬆️PO4 in CKD ✅Empagliflozin-⬇️CKD prog #KidneyWk
🫀New 2023 Dukes criteria for IE 🫀Changes from old Duke in Major criteria (in bold 👇) ✅ E. faecalis is classified as a typical cause of IE ✅Inclusion of cardiac CT/PET for IE diagnosis ✅Surgical inspection of cardiac valve included as major clinical criteria #MedX
The 100-mg dose of the new RSV antibody nirsevimab (Beyfortus) approved to prevent severe disease in infants is in short supply. The CDC has recommended prioritizing its use to those at highest risk. #RSV #MedTwitter #TwitteRx bit.ly/499DVqo
Medical News in Brief: Esketamine More Effective Than Quetiapine for Hard-to-Treat Depression ja.ma/3Sa99rH
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