Dnyanesh Rasale
@DnyaneshRasaleSenior Scientist, Oligonucleotide Chemistry : RNA therapeutics👨🔬: PepTides: DNA/RNA : @ Systems Oncology
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Interesting read: Chemical Synthesis of Modified RNA #Oligonucleotides onlinelibrary.wiley.com/doi/10.1002/an…
Can we solve endosomal escape? “If it were that trivial we would have done this over 50 years ago” Steve Dowdy @UCSDHealth @OTSociety Montreal Meeting.
Congratulations to members of the @ChaputLab on their recent publication in Nature Catalysis, describing the evolution of a new TNA polymerase for synthetic biology. We are finally closing in on the rates of natural polymerases! nature.com/articles/s4192…
Go RNA!!!
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Congrats to Ryuta Shioi on the publication of his review on new chemistries available for RNA modification -- DOI: 10.1039/D4SC05317F
Hey, senior PhD students working on RNA and moving toward leading independent labs: Apply for the Maraganore Early Independence Fellow program at @UMassChan @RTI_UMassChan and come work with us! linkedin.com/posts/angelame…
Our group's research has been published in NAR, demonstrating that 2'-formamide-modified nucleic acids can reduce the off-target effect of siRNA while maintaining its on-target effect. This work is attributed to Dr. Nomura and Dr. An. Congratulations! academic.oup.com/nar/advance-ar…
Interesting read: Structure–Activity Relationship of Antibody–Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody–siRNA Conjugates for Drug Development #Oligonucleotides pubs.acs.org/doi/10.1021/ac…
Interesting read: Discovery of a new class of cell-penetrating peptides by novel phage display platform #Oligonucleotides nature.com/articles/s4159…
Interesting read: Site-specific regulation of RNA editing with ribose-modified nucleoside analogs in ADAR guide strands academic.oup.com/nar/article/52…
#RNA oligonucleotide is an emerging therapeutic modality to treat undrugable disease. Yet, any sustainable improvement towards #oligonucleotide manufacturings will be a key advantage! Interesting read: nature.com/articles/s4158…
An honor to announce our book has been published! Many thanks to Martin Pettersson, the team at Wiley, and all our amazing contributors for making this exciting project happen! onlinelibrary.wiley.com/doi/book/10.10…
Alyssa is the first patient to receive a base edited therapeutic (triply base edited CAR-T cells that cleared her T-cell leukemia), doing well now more than two years post-treatment thanks to the efforts of Waseem Qasim’s team and GOSH.
Congratulations Alyssa! 🏆 Exactly two years on from the day she began her life-changing clinical trial, Alyssa attended a special ceremony last night, sweeping not just one but two awards! 'Young Person of Courage' and the 'Young Person of the Year 2024'.🌟 @LeicsLieutenant
Cyclopropenes as Chemical Reporters for Dual Bioorthogonal and Orthogonal Metabolic Labeling of DNA (Hans-Achim Wagenknecht and co-workers) @KITKarlsruhe #openaccess #BioorthogonalChemistry onlinelibrary.wiley.com/doi/10.1002/an…
Chemical Synthesis of Modified RNA (Ronald Micura and co-workers) #AngewandteReview #openaccess @uniinnsbruck onlinelibrary.wiley.com/doi/10.1002/an…
Surprisingly, it turns out you can place aromatic rings directly on RNA 2'-hydroxyls in water. doi.org/10.1002/anie.2…
Building short DNA/RNA fragments by Resonance Acoustic Mixing (RAM). Thanks @JamesDThorpe and of J. Marlyn @DamhaLab and S. Koenig @genentech). Also special thanks to @TomislavFriscic lab for his encouragement and showing us the way to @Mechanochem doi.org/10.1039/D4MR00…
Peptide Stapling by Crosslinking Two Amines with alpha-Ketoaldehydes through Diverse Modified Glyoxal-Lysine Dimer Linkers (Gong Chen and co-workers) @NKU1919 onlinelibrary.wiley.com/doi/10.1002/an…
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Nucleobased
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Michael Smietana
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Chaput Lab
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Deepak K. K. Kori
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Rohit Jadhav
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Debanjan Bagchi । দেবাঞ্জন বাগচী
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Amitabha Das
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Byron Purse
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Dr. Yuvraj Patil
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Alexandre
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