Brian Sheridan
@BSheridanLabAssociate Professor, Stony Brook University Renaissance School of Medicine Mucosal Immunologist All disease begins in the the gut
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Our new paper! Out now in @JExpMed! 🧵 Retinoic acid during T cell activation in lymph nodes licenses gut tissue-resident memory CD8 T cell development. Led by a very talented postdoc @ZhijuanQiu rupress.org/jem/article-ab…
Looking forward to a great week of Mucosal Immunology!
Kicking of the second edition of the “Advance Course in Mucosal Immunology” ACMI in Rio de Janeiro 😍 Great location and exciting line up of speakers! A great week of mucosal immunology ahead! @LAMIGmucosa @socmucimm @OralGut #mucosalimmunology #ingutwetrust…
Kicking of the second edition of the “Advance Course in Mucosal Immunology” ACMI in Rio de Janeiro 😍 Great location and exciting line up of speakers! A great week of mucosal immunology ahead! @LAMIGmucosa @socmucimm @OralGut #mucosalimmunology #ingutwetrust…
And yet she lost to a rapist and convicted felon whose stated intent is dictatorship and emulating Hitler. A pity she had everything she everything she needed to win except a penis.
"What did [Harris] do? She raised an insane amount of money. Her introduction to the country went well. The convention was a success. Her convention speech was a success. She crushed him in the debate, and she closed stronger than he did. She hit her marks." -@jheil
Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @Nature Huge effort by @Akaron0884 & @BrennethS and the team and collaborators to work this out. Aaron's Tweetorial 👇 nature.com/articles/s4158…
Role for IL-33 in increasing the number of T cells that commit to intestinal tissue residency in vivo during local infection @J_Immunol doi.org/10.4049/jimmun…
4/ The answer: T-bet controls sensitivity to retinoic acid (RA), a vitamin A metabolite essential for licensing TRM development in the gut (recently shown by @BSheridanLab). Meanwhile, liver TRM also rely on RA—instead of TGF-β—to guide their formation.
Great new story that increases our understanding of the cues that shape Trm heterogeneity across different tissue compartments!
1/ 🚨 Hot off the press! 🚨Our new paper, led by @ObersAndreas & @maxevrard, is now live in @ImmunityCP! 🧬 Curious how CD8+ tissue-resident memory T cells (TRM) adopt their fate in different organs? Let’s dive in! 🧵👇 authors.elsevier.com/c/1jw~j_OR~yiO…
It was a pleasure hosting @Immuno_Mike Very exciting work that I look forward to reading soon! Great systems to study #UnconventionalTcells
It was a pleasure to present our work on @CellsMait at @StonyBrookMed & have engaging discussions with @BSheridanLab @CharlesVorkas @devarajan_priya & the other faculty & trainees!
1/6 In the Oct issue @JExpMed, we publish a series of reviews on #Thymus and #TCell Development (rupress.org/jem/search-res…). We would like to thank all the authors for this incredible and coordinated effort! #Thymus #TCellDevelopment #Tolerance #Autoimmunity #Regeneration
I'm so excited to be co-running this @KeystoneSymp! We'll be hearing some titans of T cell immunology talking about differentiation in tissues! Abstracts are due November 5th! Put one in and come have a great time with us! #KSTCells25 keysym.us/KSTCells25
Human intestinal organoids containing viable tissue-resident memory T cells will facilitate the exploration of tissue–immune interactions and clinically relevant immune pathologies @NatImmunol N&V nature.com/articles/s4159… on @Nature nature.com/articles/s4158…
New study alert: Naive CD4+ T cells are heterogeneous. Some experience environmental type I IFN signaling and are poise for Tcm fate
.@deeksha_deep, Gudjonson, Rudensky et al. @MSKCancerCenter identified two distinct differentiation paths for effector and precursor central memory T cells arising from heterogeneous naïve CD4+ T cells. hubs.la/Q02R75w70 #LymphocyteBiology #Autoimmunity
Novel homing receptor identified! Now we know how to send T cells to the lungs, non-intestinal mucosae and CNS “Our results define a GPR25-CXCL17 chemoaffinity axis with the potential to integrate immunity and tolerance at non-intestinal mucosae and the CNS”…
Happy to see this commentary about most recent updates in the gamma delta world from @CoffeltLab and myself out. Happy reading.
#GDTcellclub invites you to some fantastic upcoming webinars in 2024. Pls contact our organizing team if you have any questions/concerns/nominations for future speakers :) #SavetheDates. Zoom links will be posted for individual talks!
Our latest one is out @Nature ! We found an aberrant immune epithelial progenitor niche drives post viral lung inflammation and fibrosis #LongCovid. We also pointed out potential therapeutics. nature.com/articles/s4158… Shout-out to @hnarasim23 and @wqian1016 @PeterChenMD @zangcz
Think you know how granzymes work? Think again! GzmA protects against intestinal Salmonella infection, but GzmB helps Salmonella, and perforin has no role at all. Read about this complex story of the battle between host and pathogen here tinyurl.com/2enehsx9 Tweetorial below
😲
2/ Read the @Nature publication below. A decade of work - the flexibility of the γδ TCR receptor to recognise a wide array of binding partners underscores the unique role it plays in the human immune system. @MonashUni @Monash_FMNHS @MonashResearch nature.com/articles/s4158…
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