Akash Singh
@AkashksinPhD life ..Knows something about everything 😎 Epigenetics and Neuroenthusiast.JNCASR...Behaviouranalyst.. !!🐀👨🏻🔬 Loves hiking..happiest on mountains..🤩⛰️
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Happy to share that our work has been featured on the cover of ACS Chemical Biology. 🎉🏂 #acs #Neuroscience pubs.acs.org/toc/acbcct/cur…
I'm thrilled to share that a part of my doctoral work "Epigenetic Modulation Rescues Neurodevelopmental Deficits in Syngap1+/- Mice" has been accepted for publication in Aging Cell! I look forward to sharing the full study with you all soon #Neuroscience #Health #Therapeutics
Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model: Cell Reports cell.com/cell-reports/f…
KAT5 (Tip60) acetylates chromatin protein PC4, which is critical for DNA damage repair. This could be the first report of any non-histone chromatin protein acetylation by Tip60, with functional consequences. biorxiv.org/content/10.110…
Epigenetic target for Autism/Intellectual Disability (ID): We have discovered that the downregulation of histone acetylation (presumably mediated by p300/CBP) could be a signature of SYNGAP1 related ID and could be targeted for therapy. biorxiv.org/content/10.110…
Our latest work, highlighting the role of p300/CBP lysine acetyltransferases (KAT) and histone acetylation in Autism/Intellectual disability. This work demonstrates amelioration of Autism/ID pathology by a p300/CBP specific KAT activator.
Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits biorxiv.org/cgi/content/sh… #bioRxiv
Fascinating to see progress of Tapas Kundu @jncasr and collaborators @jncasr with using carbon nanospheres TTK1 conjugate to activate CBP-p300 with #autism Syngap1 mouse model. Impressive restoration of dendritic branching and restoring neuronal plasticity. #AsilomarChromatin
Delighted to share our new findings, which show that orally administering a p300/CBP-specific KAT activator enhances motor functions and histone acetylation dynamics in a spinal injury rat model. Emphasizing CSP's potential as an oral drug delivery system. x.com/biorxiv_neursc…
Oral administration of a specific p300/CBP Lysine acetyltransferase activator induces synaptic plasticity and repairing spinal cord ... biorxiv.org/cgi/content/sh… #biorxiv_neursci
Fascinating footage of a human white blood cell chasing a bacterium captured through a microscope. Credit: David Rogers
Let's Find out what we can learn from today's #INDvPAK #T20WC2022 #FunHour #FunHourOfficial #LearnWithFunHour #ViratKohli #GOAT𓃵 #RohitSharma #hardik #KLRahul𓃵 #ICCT20WorldCup2022 #IndiaVsPakistan #INDvsPAK2022
Altmetric – CBP/p300 activation promotes axon growth, sprouting, and synaptic… plos.altmetric.com/details/136163…
What A Match..!! India Won By 6 Wickets 🔥 #RohitSharma𓃵 #RohitSharma #INDvsAUST20I
Epigenetic treatment in mice improves spinal cord regeneration after injury, according to new research led by @digiovannilab + published in @PLOSBiology imperial.ac.uk/news/239933/ep…
#TheHindu - @jncasr 's novel molecule prevents #obesity in mice. @DrJitendraSingh @srivaric thehindu.com/sci-tech/scien…
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