Tony Zeng
@tkyzengGenetics PhD student at Stanford with @jengreitz and @jkpritch
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🧬GWAS is fundamental in drug discovery, linking disease to genetic variants. However, studying rare and uncommon diseases with GWAS is hard due to the huge sample sizes required. How can we use AI to help GWAS with small cohorts? In a multi-year collaboration @GSK…
For many traits there is a correlation between the number of duplications or loss-of-function (LoF) mutations someone carries, and their phenotype. Curiously, for most traits, these effects are aligned in the SAME direction. Why?
Excited to share our work on alternative splicing (AS) rdcu.be/dSHtu. This version, compared to the biorXiv one, is much more succinct due to word limits; I hope you will have a look. Congrats to @BenjaminFair3 and @cfbuenabad for their incredible work!🧵⬇️
I attempted to put this awesome work in @NatureGenet by @spence_jeffrey_, @tkyzeng, @Hakha_Most, and @jkpritch into context in my first ever News & Views piece nature.com/articles/s4158… (free access: rdcu.be/dNOLE) 🧬
How constrained is each gene in the human genome? Our work on estimating gene constraint using loss-of-function mutations along with gene features (expression patterns across tissues, protein language model embeddings, etc...) is now officially out! 🧵/8 nature.com/articles/s4158…
Thrilled to share the bulk of my PhD work, now up on bioRxiv! This project brings together aspects of network theory, systems biology, and single cell genomics, towards understanding properties of gene regulatory networks (GRNs). Read on for more —> (1/) doi.org/10.1101/2024.0…
I'm delighted that our GeneBayes paper reporting highly accurate and interpretable estimates of gene constraint (against LOF mutations) is out now! GeneBayes builds on pioneering work on pLI + LOEUF from groups at Broad, and work on s_het + hs from Sunyaev and Przeworski labs.
How constrained is each gene in the human genome? Our work on estimating gene constraint using loss-of-function mutations along with gene features (expression patterns across tissues, protein language model embeddings, etc...) is now officially out! 🧵/8 nature.com/articles/s4158…
How constrained is each gene in the human genome? Our work on estimating gene constraint using loss-of-function mutations along with gene features (expression patterns across tissues, protein language model embeddings, etc...) is now officially out! 🧵/8 nature.com/articles/s4158…
Excited to share the first part of my PhD in the @jengreitz lab, co-led with @gabmartyn We developed and applied Variant-FlowFISH, a new high-throughput technology to measure the quantitative effects of hundreds of designed DNA edits on gene expression doi.org/10.1101/2023.1…
Our work on computing likelihoods under the Discrete-Time Wright-Fisher model is out now in @GeneticsGSA . We used our machinery to look at recurrent mutation in large samples and see how demography and sample size interact when estimating selection academic.oup.com/genetics/artic…
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
I'm thrilled to announce that I've joined the Section of Genetic Medicine at the University of Chicago as an assistant professor! The Simons lab is officially open! yuvalsimons.org
Thrilled to share that I'll be joining the Center for Human Genetics & Genomics at the NYU Grossman School of Medicine as an Assistant Professor in December 2023! @nyugrossman @nyulangone
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