Stephen Chin
@schin_au#radonc in mainly GU, thoracic, lower GI & gyn ca. interests in palliative onc, #brachy, SABR, MR in RT
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Transformative clinical trials in gynaecologic radiation oncology in 2023-2024: Shaping modern treatment practices pubmed.ncbi.nlm.nih.gov/39580331/ Great review of key papers in gyn - cervix, endo CALLA, A18, OUTBACK, INTERLACE, EORTC 55994 B21, LUNCHBOX
✨Our systematic review focusing on TMT and concomitant Chemo regimen for patients with MIBC 👉 Heterogeneity ++ 👉Overall, similar OS and safety outcomes 👉Highest LOE=5FU-Mitomycin C 👉Data regarding elderly patients and QOL insufficiently reported sciencedirect.com/science/articl…
@AlbertoBossial #PEACE 1 RT arm just dropped in @TheLancet Systemic Rx (61% doce 50% abi) + RT ↑ time to CRPC +GU toxicity for BOTH low and high-volume pts +↑ PFS for those on abi. RT for all! Article: tinyurl.com/5n9ayvfk @cristian_udo Editorial: tinyurl.com/vetmeu86
New in #practicalRO: Stereotactic Body Radiation Therapy for Primary Lung Cancer and Metastases: A Case Based Discussion on Challenging Cases. #radonc tinyurl.com/proplee1
Interesting results😱 from the Phase III OPERA trial show that adding contact X-ray brachytherapy (CXB) to chemoradiotherapy in early rectal adenocarcinoma significantly improves outcomes. 📊 Key statistics: ▶️5-year organ preservation rate: CXB 79% vs. 56% (p=0.004). ▶️For…
Overtreatment of Prostate Cancer Among Men With Limited Longevity in the Active Surveillance Era jamanetwork.com/journals/jamai… via @TimDaskivich et al @VincentGnanapr3 @LondonProstate1 @MichaelBaum11 @susan_bewley @paulpharoah @naserturabi
Not surprised as few urologist/oncologist really understand prognosis and competing risks as we showed previously and till now many refuse to promote and include unbiased prognostic models in their clinical practice - no matter how much evidence there is ! nature.com/articles/s4141…
New Video! Cardiovascular risks of ARSIs in #ProstateCancer: Meta-analysis findings. @RKSayyid @USC & @zklaassen_md @GACancerCenter emphasize the importance of comprehensive cardiovascular assessment before initiating ARSI treatment > bit.ly/3TJ1lNy @JAMAOnc
Interesting observation: - Continuous increase in AE over time after both RT surgery - Curves are perfectly in parallel after about 3.5 years, not showing any excessive risk of AE after RT vs surgery until 12a
New insights into Long-Term Adverse Effects and Complications After Prostate Cancer Treatment, Radiotherapy and Prostatectomy 👉 Both associated with increased risks of AE compared to untreated pts 👉 Cumulative 12-year risks of AE 61% vs 42% after Prostatectomy and Radiotherapy
How to untangle and interpret CT scan appearances post-SABR? Dr Arya Amini and Dr Henry Park give us a great decision tree in their publication today in @ASTRO_org Practical Radiation Oncology 🔗practicalradonc.org/article/S1879-…
AI-derived Tumor Volume from Multiparametric MRI and Outcomes in Localized Prostate Cancer pubs.rsna.org/doi/10.1148/ra… 👍AI-segmented intraprostatic tumor volume can predict surgery and radiotherapy outcomes in localized prostate cancer. 🎉Congratulations to Authors of this nice…
SBRT for localized prostate cancer - the new SoC ? ! All questions to PACE-A and PACE-B studies answered by Prof. N. Van As Virtual Grand Rounds in Radiation Oncology November 6th, 17:00 - 17:45 CET Link to Zoom meeting on homepage 👇 lnkd.in/e32jAfAf
Don’t lie!! Do you just say a lesion is in the white matter & move on? Do you just corona radiata or centrum semiovale & hope no one asks questions? That’s like saying a fracture is in “the leg” & moving on! Just like cortical regions have function, so does the white matter!…
Patient-centered care means ensuring that we provide our patients with all available options, empowering them to make informed decisions that best align with their needs and preferences #SIU2024 #SIU2024NewDelhi @WorldBladderCan @BladderCancerUS @PGrivasMDPhD @shilpaonc…
Impactful start to #SIU2024 this morning with @UroDocAsh highlighting likely shifts in MIBC landscape..relevant for organising treatment pathways @TataMemorial & @ACTREC_TMC @VedangMurthy @dramandeeparora @AmitJos93188352 @docpriyamvada @IBCG_BladderCA
Impactful start to #SIU2024 this morning with @UroDocAsh highlighting likely shifts in MIBC landscape..relevant for organising treatment pathways @TataMemorial & @ACTREC_TMC @VedangMurthy @dramandeeparora @AmitJos93188352 @docpriyamvada @IBCG_BladderCA
Thoracic Radiotherapy Improves the Survival in Pts With EGFR-Mutated Oligo-Organ Metastatic Non-Small Cell #LungCancer Treated With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors: A Multicenter, Randomized, Controlled, Phase III Trial brnw.ch/21wNZM6 #NSCLC
Diet Quality, Dietary Inflammatory Potential, and Risk of Prostate Cancer Grade Reclassification out on @JAMAOnc jamanetwork.com/journals/jamao… Study explores the relationship between diet🍲 and the risk of prostate cancer grade reclassification in 886 men with grade group (GG) 1…
Here's long-term efficacy for intermediate risk patients only led by @cristian_udo: 2 fractions - #2STAR, #2SMART 5 fractions - #PATRIOT, #PHART6 Currently under review
HERMES interim toxicity: redjournal.org/article/S0360-… 3/3, oops, can’t count :) 2 Fx SBRT is promising.
MultiD management of locally advanced NSCLC: Rapidly moving, complex + exciting area🔥 ➡️Honor/privilege to work on @STS_CTsurgery recs🙏 ➡️Appreciate inclusion of #medonc #radonc 👍 @biniamkidaneMD @theabzlab @JoelNealMD @BrendonStilesMD @JustinGainor annalsthoracicsurgery.org/article/S0003-…
Thomas Kennedy leads @Sunnybrook long-term (->16y FU) prostate #SBRT paper in @ASTRO_org @IJROBP Free link here 👉authors.elsevier.com/a/1jsVS1Hx52K0… 99% Freedom from Mets 4-5% 10y recurrence risk for low or fav int risk (note 0% failure for LR 40/5) 1% 2nd cancers likely due to RT
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