Ryan Tewhey
@r_tewheyAssociate Professor at The Jackson Laboratory -- Studying gene regulation, genetic variation & human complex traits.
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Excited to share our latest preprint, as part of ENCODE4, on a consensus variant-to-function (cV2F) score for functionally prioritizing variants for complex disease - led by Tabassum Fabiha and co-mentored with Alkes Price. biorxiv.org/content/10.110…
Excited to share our sequence design work published in @Nature I had the privilege of co-leading this effort alongside my friend and colleague @SagerGosai under the supervision of @r_tewhey, @ReillyLikesIt, and @PardisSabeti nature.com/articles/s4158… 1/7
Using #AI, a Broad/@jacksonlab /@YaleMed team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. broad.io/CRE-AI @ReillyLikesIt
🔥🔥🔥 new paper out from Steven Reilly @ReillyLikesIt together with Ryan Tewhey @r_tewhey led by Sager Gosai @SagerGosai + Rodrigo Castro @i_rodcast Synthetic cis-regulatory elements (CREs) that drive cell-type-specific gene expression 🧬🤯 nature.com/articles/s4158…
The lab’s second paper biorxiv.org/content/10.110…, led by the talented Alex (Ching-Huang) Ho in my group, focuses on connecting non-coding autoimmune variants to primary T cell expression and function! (1/n)
Fantastic scMPRA approach from @jb_lalanne, @SRegalad0 & @JShendure Lots of great observations buried in the supplemental too!
After a constructive set of reviews, our single-cell reporter work is OUT nature.com/articles/s4159… Check out the briefing if you want the tldr nature.com/articles/s4159… I am particularly fond of some of the new applications. Mini-update.
After a constructive set of reviews, our single-cell reporter work is OUT nature.com/articles/s4159… Check out the briefing if you want the tldr nature.com/articles/s4159… I am particularly fond of some of the new applications. Mini-update.
Two excellent sets of take-home impressions from @s_ramach and @ewanbirney on #BoG24. I'm going home excited and inspired by the science presented this week. A few impressions from me 1/
A great summary of #BoG24 by @ewanbirney - not much I can add except 1/
Had a great time hanging out with the @TewheyLab ! Thanks @r_tewhey and @jacksonlab for hosting us!
I'm thrilled to share my thesis work with @BarakACohen and @genologos! We answer the question: what do you do after measuring all cis-regulatory elements (CREs) in the genome? Our proposed solution: active machine learning. 1/n biorxiv.org/content/10.110…
This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.110… 1/n
Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ @r_tewhey @TewheyLab
GSBS congratulates our 2023-24 Dean's and Rosenberg Fellows: Abby Lemons, @MDKrasilnikov, Morgan McNellis, and @niketa_n!
Excited to share our updated HiDRO paper in @nature rdcu.be/dgGge! We used HiDRO to screen for druggable regulators of 3D genome folding. We further characterized a novel noncanonical function of GSK3A in regulating cohesin. Brief summary highlighting what’s new: 1/
Our HiDRO paper is now published in @Nature nature.com/articles/s4158… Since the preprint, we made a few key additions worth checking out. Thanks to reviewers for their helpful suggestions! Original tweetorial posted below:
![[Ran by: Laura Blanco-Berdugo]
The Dumont lab focus on the mechanisms that generate genetic diversity through the lens of evolution.](https://pbs.twimg.com/profile_images/1529162226447294464/LrdHUvyk.jpg)
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