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Severe Tropical Infections ■Send the investigation according to the presenting syndrome 1. Fever with a rash/thrombocytopenia: *dengue serology, platelet count, chikungunya serology, meningococcal serology, rickettsial serology, Widal test (typhoid), Epstein–Barr virus…
Acquired angioedema (AAE) due to deficiency of C1-inhibitor *Severe, sometimes life-threatening, episodes of angioedema *Usually occurs in adults over 40 years of age and there is no familial predisposition *Typically affects the face, the oropharyngeal and laryngeal…
Acquired angioedema (AAE) due to deficiency of C1-inhibitor immunology.org/public-informa…
Radiation associated cutaneous mastocytosis! We describe a case and review the literature of this extremely rare phenomenon. pubmed.ncbi.nlm.nih.gov/39143718/
Intraocular melanoma is an ocular melanoma that accounts for ~ 85% of all cases. It is characterized by the development of metastatic disease, with up to 50% of patients experiencing metastasis. Liver metastasis is a common feature of uveal melanoma. h/t @AaronGoodman33 @Sthanu5
My first Twitter spaces with @chadinabhan where will discuss heme onc fellowship and how to survive, learn, be successful and have fun.
The @AaronGoodman33 and I are planning to host a twitter space for heme onc fellows and residents thinking of a heme onc fellowship. Working on identifying the right time. Follow for details but please answer the poll if interested,
For the fellows. Doctor (squared) Russler-Germain always has great content that he shares.
I’ve been asked to re-share some of my lymphoma teaching resources from @WUHemeOncFellow So glad people find them useful! Focused review of RT for DLBCL: wustl.box.com/s/u04583yxw92e… Broad review of DLBCL for first year fellows: wustl.box.com/s/ekrn9y9rka1c…
The Goodman has 100k !! What a fabulous account to follow, a must follow if not already. Tweets gems every single day 👍🏻 @AaronGoodman33 #MedTwitter
There is a fungus among us, updated! Fluconazole = candida (not Krusei/Glabrata)+crypto+cocci Itraconzole = Fluconazole+ histo +blasto+aspergillus Voriconazole = Itraconazole, drug of choice aspergillus Posaconazole = Vori+mucor Isavuconazole = Posa but less drug interactions
Antifungal Board Review! A patient is diagnosed with invasive aspergillosis. Of the following choices, which is the most appropriate treatment choice?
Riedel thyroiditis. Inflammation with extensive fibrosis which may mimic cancer. Can potentially famage adjacent structures causing dysphagia and horseness of voice. Linked with IgG4 related inflammatory disease.
Continuing my review of the Thyroid! I had forgotten about this entity. Buzz words "stone like" "non tender" thyroid. ncbi.nlm.nih.gov/books/NBK53730…
My Favorite Medical Mnemonic of All Time! Feel free to share yours Causes of Pancreatitis I GET SMASHED Idiopathic Gallstones Ethanol Trauma (steering wheel) Steroids Mumps/Malignancy Autoimmune Scorpion sting (from Trinidad!) Hypertrygliceridemia/Hypercalcemia ERCP Drugs
Transfusion medicine for RBCs - 1 Tweet pRBC = ⬆️250-300 mL volume ⬆️O2 carrying capacity Leukocyte reduced ⬇️Febrile nonhemolytic reactions ⬇️CMV ⬇️HLA alloimmunization Irradiated = ⬇️Transfusion GVHD Washed = ⬇️Allergic/anaphylactic Rx Use in IgA deficient patients
Fellows - How I keep up with the Heme Literature! 1. Every Thursday scan abstracts Blood JCO TCT NEJM Lancet Onc/heme Download imp papers 2. Read ASH Ed+SAP every year (cover to cover) Download imp papers 3. Twitter (follow key people) 4. Read above papers for clinic Pts
Reading lots of ASH abstracts with the conclusion “drug X was well tolerated”. Did you ask the patients if they thought it was well tolerated when over 10% were hospitalized from a complication of the treatment? @MyelomaAmateur @barttels2
Hematology Gold for Medical Students, Residents (and even Fellows) @Bloodman world famous Handouts! Free Concise I read these all the time and then teach on rounds. tinyurl.com/yyb6645v
Oncology Pharma Thesaurus - ASH is soon, so don't forget Game changer = <50% chance FDA approval Novel = Expensive yet ineffective Chemotherapy free = Chemotherapy No significant tox = Deaths reported Manageable toxicity = Requires dedicated palliative care team (selinexor)
Amazing talk by @AaronGoodman33 Important messages from the world of myeloma that are relevant for many other cancers!
PFS is a poor surrogate endpoint for OS in multiple myeloma trials. So maybe we should stop using it so much? Paper: Time to Event Surrogate Endpoints in Multiple Myeloma Randomized Trials from 2005-2019: A Surrogacy Analysis ash.confex.com/ash/2022/webpr…
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