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@changukchungPostdoc in Gleesonlab at UCSD and incoming professor in GSMSE at KAIST. Interested in various genetic and physiological profiles in normal and diseased brain.
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Check out our new biorxiv post focused on origins of neural crest-derived peripheral nervous system ganglia! We used mosaic variant barcode analysis to resolve clonal lineage in humans.
1/n Today in @ScienceMagazine: ‘Risk of meningomyelocele mediated by the common 22q11.2 deletion’. science.org/doi/10.1126/sc…
today.ucsd.edu/story/followin… naturally-occurred mosaic variants enabled a unprecedented direction to understand development, especially in humans, glad to be part of this
Excited to announce our latest research on clonal dynamics within the human forebrain, now published @Nature! A huge shoutout @shishenyxx and all the co-authors for their collaboration. Immense thanks to @jogleeson_ucsd for his great supervision. nature.com/articles/s4158…
Our new ms “Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain” is now at @Nature . rdcu.be/dEmgT! We report on human forebrain dynamic assembly during development…1/n
“Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain”, by @changukchung @shishenyxx @jogleeson_ucsd and collaborators, now out in @Nature nature.com/articles/s4158…
Human neocortex development is highly dynamic and guided by cell-type-specific gene regulation, the details of which remain elusive. Our new work from @Kriegsteinlab and @jingjingSF applys multi-omic spatiotemporal profiling to address this issue.(🧵1/n) biorxiv.org/content/10.110…
Our bioRxiv preprint highlighted by @_TheTransmitter @ElissaWelle, on our and @ChrisAWalsh1's still unpublished evidence of partial shared origin of excitatory and inhibitory cortical neurons. thetransmitter.org/interneurons/c…
Lots of insights about arealisation of the human cerebral cortex in this new preprint by @snk_kim V. Viswanadham @peter_j_park and @ChrisAWalsh1, exploring the effects of somatic mutations 🧠🧬 biorxiv.org/content/10.110…
Check our new ms showing dorsal neocortical origin of inhibitory neurons that disperse radially from origins shared with excitatory neurons. "Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrain". @changukchung @shishenyxx biorxiv.org/content/10.110…
Fascinating paper on prezygotic aneuploidy and postzygotic reverts! @jogleeson_ucsd @shishenyxx and I have summarized our thoughts and hypotheses on this research. #Genetics #somatic #mutation @NatureGenet nature.com/articles/s4158… nature.com/articles/s4158…
Neocortical Neurogenesis in Development and Evolution edited by Dr. Wieland Huttner is an extraordinarily up-to-date resource. For instance, the discovery of excit + inhib dual lineage cortical progenitors last year has already been discussed and reflected on the illustration.
Evolutionary theorists have proposed that #neoteny is a key feature in human #evolution. Is it true? Our new paper at @Nature provides some insights into this topic—the slower development of synapses may contribute to our unique cognitive function. (1/12) nature.com/articles/s4158…
In our new paper from @Kriegsteinlab, we demonstrate that LIF promotes outer radial glial cell (oRG) proliferation and differentiation into interneurons. This work is done through an amazing collaboration with @Andrews_MG and @siebert_clara (1/6) cell.com/cell-stem-cell…
We could perform volumetric near-infrared light sheet imaging with WHaloCaMP in zebrafish larvae together with twitterless Philipp Keller and Bill Lemons on their #SiMView. I never tire of watching this movie .
Modeling alterations in forebrain development between boys with #autism and their unaffected fathers using cortical organoids suggest changes in macrocephalic and normocephalic probands involve opposite imbalances between cell types nature.com/articles/s4159…
Delighted our paper on polymicrogyria (PMG) is out today @JAMANeuro! How does the cortex get its shape? Great work from twitterless Shyam Akula, Allen Chen, with support from Allen Brain Evolution Center @AllenFrontiers @broadinstitute @BostonChildrens @HHMINEWS @NINDSnews
Postdoc @changukchung from @jogleeson_ucsd lab has gone through almost 10,000 pipette tips this week, validating #brain #somatic #mutations this week. This work is not for the faint of heart!
New study from our lab 🧬: using trace tissue from SEEG electrodes, we detected somatic mutations in mTOR pathway genes, causing epilepsies due to focal cortical dysplasia. 👉Potential link between mutation load to epileptic activity & improved diagnostic. @SaraBaldassari4
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Who to follow
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Joseph G. Gleeson
@jogleeson_ucsd -
Hyoseon Oh
@Hyoseon_Oh -
Laurent Nguyen
@neuroliege -
Joon-Hyuk Lee
@JoonHyukLee3 -
Matteo Ruggiu, PhD 🇺🇦
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Sara Bizzotto
@sarabiz86 -
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@Soowon_L -
Xiaoxu Yang
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Xuyu Qian
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Seahyung Park
@SeahyungPark -
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Harry Keng Ioi Vong
@HarryKiv -
jkbenotmane
@jkbenotmane -
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