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🎉Excited to present our latest work out today @Nature 1.What gives a leukemia its phenotype – the oncogenic driver or the differentiation stage of the cell-of-origin? 2.Why do RAS mutations always happen late in AML? 3.Who will relapse after VEN? nature.com/articles/s4158…
Proud of all authors of our paper showing RUNX1 is activated by CDK9 to promote megakaryocyte fate in primary human progenitors. Let us know what you think! @NKwonHem @EvrettT @mancuso_rubia @Yalelabmed @Yale_LabMed @RUNX1Research authors.elsevier.com/a/1j%7EX21UYwn…
Previous studies have shown self-reported Black patients have inferior treatment and survival outcomes compared to White patients, but why? Our work indicating that underlying genetics influence AML biology is now live at @NatureGen! 🎉🎈🍾 nature.com/articles/s4158…
Very proud that our discovery that phophoserine RUNX1 promoted megakaryocyte (MK) fate specification in primary human MEP is out! @YaleCCEH @Yale_LabMed Work of many including the amazing @NKwonHem sciencedirect.com/science/articl…
Our Human Bone Marrow CITE-Seq Portal (altanalyze.org/MarrowAtlas/) now hosts video and step-by-step walk through tutorials for: 1) Supervised scRNA-Seq annotation (Azimuth) 2) Comparative visualization of RNA & ADTs (ShinyCell). Please see the on-page and Synapse download links.
AND.....special thanks to @kathrinbernt insightful review of our latest atlas paper! 🌟 nature.com/articles/s4159…
We provide an interactive web portal for supervised classification and cell surface marker imputation (Azimuth), multimodal CITE-Seq ShinyCell browsers and donor expression viewers at altanalyze.org/MarrowAtlas/. Collaborators @LeeGrimesLab @Krauselab_Yale @CraigTJordanLab Singh lab
Excited to announce our Human Bone Marrow Progenitor Atlas (doi.org/10.1038/s41590…). >80 rare stem/progenitor states delineated through multimodal (CITE-Seq) integration w/ prior cell atlas labels (scTriangulate). Validated by InfinityFlow, sorting & in vitro differentiation.
This is team science! 🤝 A big shoutout to @LeeGrimesLab, @Krauselab_Yale, @PittTweet (Singh lab) & @CraigTJordanLab Funded mostly by an RC2 grant from @NIH, @NIDDKgov, @ShilpaH75 Kudos to @BioLegend, @CytekBio & Curiox Biosystems for their support with prototype products! 3/3
Check out our digital resource for everyone in #hematology! altanalyze.org/MarrowAtlas/ Visualize any gene and surface marker on 80+ cell states from >400k human HSPCs from donors spanning race and sex. Check the Infinity Objects for isolation strategies of your cell of interest. 2/3
I am really pleased to share our latest manuscript, just published @Nature! You can access the manuscript (open access) here: nature.com/articles/s4158… Special thanks to Maria Carolina Florian for the great commentary: nature.com/articles/d4158…
🚀 Launching our #SingleCellAtlas: a deep dive into human bone marrow with paired CITE-seq and high-dimensional flow cytometry! Led by @XuanSeanZhang and @annie_song_b published in @NatImmunol doi.org/10.1038/s41590… 1/3
(1) We are excited to finally share “Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy” at Science Translational Medicine (bit.ly/4b23Gdq). SNAF is an end-to-end workflow for splicing neoantigen & transmembrane epitope prediction...
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Who to follow
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Zihan Xu
@xu_zxu -
Jason Yang
@JasonJuechen -
Taishi Yonezawa
@TaishiYonezawa -
Jack Hedberg 🧬
@jack_hedberg -
Nathan Salomonis
@nsalomonis -
DRESH
@EricHallPhD -
BettinaNadorp
@BettinaNadorp -
Smruti (Smoothie) Deoghare, PhD✨
@DeoghareSmruti -
Kang Jin
@Kang_Jin__ -
Guangyuan(Frank) LI
@FrankLI55917967 -
ethan
@ethanpoweleit -
Bailee Kain
@Bailee_Kain
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