Ryan Cupo
@Ryan_CupoPost Doc in the @LabYoule Graduate Studies in the @ShorterLab Husband of @jordan_cupo Follower of Christ
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Super excited to share my first paper from the @ShorterLab out today in @eLife ! elifesciences.org/articles/55279 Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations
Structure and function of the human mitochondrial MRS2 channel nature.com/articles/s4159…
Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease: cell.com/neuron/abstrac…
@Pagliarini_Lab we are looking forward to your presentation at #Mito25 this coming February☀️There is only 2 WEEKS left to register, so please RT to let your followers know limited spaces remain to join us in the Dominican Republic! 🇩🇴 Register here➡️bit.ly/3zPBufN
The yeast genome is globally accessible in living cells: nature.com/articles/s4159…
In lattice light sheet microscopy, the excitation and detection pathways are orthogonal, and hence suffer different sample induced aberrations. In adaptive optical LLSM, unique corrections are applied to the two paths, with the correction becoming increasingly large with…
🚨Join the dream team to work on vitamin and cofactor metabolism/physiology! We have several post-doc positions open: job-boards.greenhouse.io/arcinstitute/j… . Email isha.jain@arcinstitute.org @arcinstitute @GladstoneInst @UCSF
Allosteric modulation of the Lon protease via ssDNA binding and local charge changes jbc.org/article/S0021-…
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation febs.onlinelibrary.wiley.com/doi/10.1111/fe…
Thanks to Chenxiao Yu, @MarcoTigano & Erin L Seifert from @MitoCareCenter for highlighting our PDE12 paper in News & Views! embopress.org/doi/full/10.10…
Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/mb…
Should we be rethinking tremor that does not respond to levodopa? Some folks quote 20-40% for this phenomenon? Swinnen and colleagues turn this notion on its head in their recent @MDCP_Journal paper were they argue with data it is actually ~4%. Key Points: - The authors comment…
Our perspective on Hsp90 as a global modifier of the genotype-phenotype-fitness map, along with its implications for evolution in nature and clinical settings, is now out in JMB. We review the existing literature, identify open questions, contextualize our recent findings on…
Correlative two color 3D super-resolution single molecule localization microscopy and block face electron microscopy of mitochondria and the endoplasmic reticulum in vitreously frozen COS-7 cells doi.org/10.1126/scienc…
Excited that my first paper as a principal investigator has been published in Molecular Cancer Research (@AACR @MCR_AACR)! We discovered how #cholangiocarcinoma (@curecc), a rare cancer, affects a type of cancer killing immune cells known as NK cells. aacrjournals.org/mcr/article-ab…
The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.110…
Excited to share our latest work in @NatureComms! We've captured an AAA proteolytic machine in action, right as it poised to unfold its substrate for degradation—a first-ever glimpse into this long-sought, elusive step in AAA proteolysis! Enjoy! rdcu.be/dZzRR
Energetic requirements and mechanistic plasticity in Msp1-mediated substrate extraction from lipid bilayers biorxiv.org/content/10.110…
Can we make Acoustic Proteins with different "colors" the way the developers of GFP made BFP, YFP, etc?🌈 Yes, via #directedevolution of #gasvesicles! Congrats to @nivinnystrom et al on the first GVs multiplexed based on nonlinear response to ultrasound. biorxiv.org/content/10.110…
Jesus said to her, “I am the resurrection and the life. Whoever believes in me, though he die, yet shall he live, and everyone who lives and believes in me shall never die.” John 11:25–26 Even though we die, we do not die. Nor will we ever die.
Chronic stress antagonizes formation of Stress Granules biorxiv.org/cgi/content/sh… #biorxiv_cellbio
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