Ralph Grand
@RalphSGrandJunior Group Leader @ZmbhH | Postdoc FMI @SchubelerLab | Interested in all levels of gene regulation in mammalian chromatin and the outdoors.
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Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…
Beyond happy to share the most exciting findings of my PhD research in the @stark_lab 🤩 tinyurl.com/k6rbxjwn Our genome-wide silencer screen revealed that silencers are different from your typical regulatory DNA element. Find out more below 👇 (1/9)
@arnaud_kr and I have been talking about organizing a single-molecule genomics meeting for years! We're excited to do so at @embl while bridging the fields of single-molecule genomics and microscopy with our co-organizers. Hope to see you there July 15-18 embl.org/about/info/cou…
Thrilled to announce a new conference focused on gene regulation mechanisms at molecular resolution. We bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy.
Thrilled to announce a new conference focused on gene regulation mechanisms at molecular resolution. We bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy.
🤩 what a lineup! Looking forward to discuss about single molecules...
Thrilled to announce a new conference focused on gene regulation mechanisms at molecular resolution. We bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy.
📜Our GATA story is finally out in its peer-reviewed format! We even added a double deletion of GATA-responsive enhancers in zygotes to show a direct connection between GATA TFs and Xist. Congratulations to all authors! nature.com/articles/s4155…
We’re excited to share our new preprint, headed by Liat Ravid Lustig and @AbhiSampKumar, where we identify the GATA family as tissue-specific activators of Xist, which are required for initiation of X inactivation in early embryos. biorxiv.org/content/10.110…. See tweetorial below
Interested in technology development 🤔 Want a stepping stone into the biotech industry with training, secondments & competitive salary? Check out the ARISE2 programme: embl.org/training/arise… If you are interested in translational applications of #CRISPR… contact me! #job
Very excited to see this paper published and to be a small part of a great team. Benchmarking @nanopore sequencing for use in the clinical setting for rapid diagnosis of rare genomic disorders. #Nanopore #RareDisease #Genomics nature.com/articles/s4152…
#Postdoc or #PhD position jointly hosted in our lab and that of Alexander Sasse @LXandR_ to investigate the evolution of gene regulation at the single-cell level across primates/mammals using state-of-the-art deep learning approaches: home.kaessmannlab.org/openPositions Please RT!
#1 key to successful start of a lab is a supportive environment with good core funding. I found this @embl under the great leadership of @Eileen_Furlong . Now it's your time! Fantastic colleagues - apply 👇👇 embl.org/jobs/position/…
Check out our latest review on how cooperativity influences transcriptional bursting. Kudos to the first author Charis Fountas! sciencedirect.com/science/articl…
Analyzing whole genome DNA methylation data? Our new method MethyLasso is out in NAR! It can help you identify regions with low or partial methylation (LMR, UMR, DMV, PMD, PMD) or differentially methylated regions (DMR) and was benchmarked against others doi.org/10.1093/nar/gk…
Our new study, initiated by an undergraduate in the lab, was set to examine the effect of mutating histone H3.3 K122 to alanine. To do so, we attempted to generate murine ES cells mutating all four alleles, but were surprised when we couldn't generate these lines!
📢Postdoc available! We are looking for curious minds to answer big questions using epigenome editing Join us at @EMBLRome - we offer training, supportive environment, top salary and scientific excellence. Also - sun, culture & Italian food😉 Info+apply: embl.org/jobs/position/…
How are promoter interactions coordinated during cell differentiation? In our first paper, we investigate the temporal relationship between genome folding, transcription and histone modifications during ESC differentiation. (1)
Exciting Masters/PhD opportunities in Adelaide Australia, balancing creativity, excellence and inclusion!! Please join if your interested in Genomics and making a difference through research!! Please share with your networks!!!
New preprint from the lab where we engineer a DNA damage sensor for live imaging and proteome analysis of DNA double-strand breaks. Work spearheaded by talented postoc @RichieCDS biorxiv.org/content/10.110…
Calling metabolism enthusiasts looking for a PhD opportunity! We have an exciting project in partnership with DefiniGEN Applications close Nov 24th findaphd.com/phds/project/i…
We have a job opening for a postdoctoral researcher in the Carl Zeiss Stiftung Center für Synthetic Genomics in Heidelberg, that also involves project management aspects. For details refer to: syn-gen.de/postdoc-positi…
Happy to share two post-doc papers co-authored with the amazing @AnaMonteagudo4 and @teresa_urli We had amazing collaborators for both projects, even our supervisor @maxvcg joined in on the experimenting! 1: pubmed.ncbi.nlm.nih.gov/39180406/ 2: rdcu.be/dXXqh
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Who to follow
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luke isbel
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Schübeler Lab
@SchubelerLab -
Arnaud Krebs
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Luca Giorgetti
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Vaquerizas Lab
@vaquerizas_lab -
Jamie Hackett
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Alicia K. Michael
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FragileNucleosome
@FNucleosome -
Robert Schneider
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Heard_Lab
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Geneviève Almouzni
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Marc Bühler
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Prof Ana Pombo
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Gene Regulation
@generegulation
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