We just published the largest study on sex-stratified mortality estimates in schizophrenia. 🧵1/10

#Psychedelics (eg #psilocybin #LSD #MDMA) linked to 4-fold risk of #psychosis in this huge, 5-year cohort study of people who visited the ED for drug use: pubmed.ncbi.nlm.nih.gov/39535804 Does not prove causation, but adjusted data showed a greater risk than with alcohol or cannabis

Antidepressant on the Horizon 👉Esmethadone 🧵1/

Wokeism is dead. Identity politics is dead. Virtue-signalling is dead. Trump’s massive win was a total repudiation of all the far-left’s ‘progressive’ (but actually regressive) crap. Common sense will now return to a world that had gone nuts, and thank god for that.

Hey Trump voters. Hate to break it to you - but here’s what actually happened on Tuesday. Watch. Bernie explained it 20 years ago.

Switching quickly between digital media doesn't reduce boredom. It intensifies it. 7 experiments: Skipping and swiping through segments to sustain interest backfires. Divided attention thwarts satisfaction and meaning. Enjoyment depends on full immersion in one task at a time.

Ice Mountains of Pluto as seen from New Horizon spacecraft.

🌟 Antibiotic spectrum overview

unpopular opinion but the whole "no drinking" vibe is correlated with a massive spike in social isolation. yes, binge drinking is bad, but going out for a glass of wine or a beer with friends on the regular actually has positive effects that outweigh the negative health…

Great review of GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity. #GLP1 #GLP1RA thelancet.com/journals/eclin…

What they can't burn 👇 The Diagnostic Process in Psychiatry consists of 1. The Diagnostic Hierarchy 2. The Diagnostic Formulation 3. The Diagnostic constructs ( DSM-5) They can burn 3 - but 1 and 2 remain untouched.

What is the most antidepressant ingredient in #CBT #therapy? "Absorption training," concludes large RCT: pubmed.ncbi.nlm.nih.gov/37378962 I agree. It was a big part of my 2020 #Depression & #Bipolar Workbook (in photo): amazon.com/gp/product/168… #psychiatry #selfhelp #mentalhealth

This is all it takes. No need to take everyone seriously. No need to waste effort in trying to convince people otherwise. My trick is to treat statements online as coming from teenagers. My need to ague falls flat

When psychopharmacology + clinical practice predicts future RCT results 😊👉 Me NOV 2023 👇 Naltrexone ✅ ✅Topiramate 50-75 mg > acamprosate or gabapentin 😁 Acamprosate has had more trials vs Topiramate but when you take into account ease of administration, mood stabilising…

Formulation Time – When Neuroinflammation meets Formulation. 🚀 (Long thread) CFS/ME, POTS, EDS, MCA, Fibromyalgia ..... What's the Diagnosis? Wrong Question! ❌ Rather, let's ask: How can we develop an individualised plan for this patient to help the patient get back to…

Pretty amazed to share that the YouTube channel hit 50K subscribers! I’ve enjoyed creating videos but what’s been amazing has been the comments and questions which have been an incredible source of learning. If you’re into concise, engaging content, delivered in a ‘YouTubey’…

POV: You are about to receive advice that will shorten your lifespan by 15 years

2023 brought a classic trial of treatment resistant #depression in the elderly in @NEJM: Aripiprazole augmentation more effective than switching to bupropion; falls worse with bupropion. When those failed, lithium and tricyclic brought equal benefits. nejm.org/doi/full/10.10…

I understand that SGLT2 inhibitors like Dapagliflozin can act as a fasting mimicker, however, assuming one eats over their daily TDEE, would the "fasting benefits" - ampk, etc, still work?

Assuming dose-equivalency and adherence to treatment, why would Semaglutide be superior to Liraglutide? Is it receptor pharmacokinetics - dissociation rate, etc? Because it doesn't make a lot of sense, given that Liraglutide is even better at penetrating BBB?